ZFIN ID: ZDB-GENE-030131-6654
Gene Name: tripeptidyl peptidase I
Gene Symbol: tpp1

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Previous Names: cln2, fa01b09, im:7149243, wu:fa01b09

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(Including Attributions)
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7149243]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  retinal ganglion cell layer, retinal inner plexiform layer, retinal outer nuclear layer, unspecified
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3587 Point Mutation Exon 11 Premature Stop ENU
sa11 Point Mutation Exon 3 Premature Stop ENU
sa2895 Point Mutation Unknown Splice Site ENU
sa6483 Point Mutation Unknown Premature Stop ENU
sa8389 Point Mutation Unknown Premature Stop ENU
Targeting reagents: MO1-tpp1 (1), MO2-tpp1 (1)
PHENOTYPE
Data: 10 figures from 2 publications
Observed in: brain, caudal commissure axon, central nervous system, central nervous system projection neuron axonogenesis (all 24) expand
DISEASE ASSOCIATED WITH tpp1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 7 Spinocerebellar ataxia, autosomal recessive 7 609270
neuronal ceroid lipofuscinosis Ceroid lipofuscinosis, neuronal, 2 204500
GENE ONTOLOGY
Ontology GO Term
Biological Process central nervous system development (more)
Molecular Function tripeptidyl-peptidase activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000209 (1)
  • InterPro:IPR009020 (1)
  • InterPro:IPR015366 (1)
  • InterPro:IPR030400 (1)
  • PROSITE:PS51695 (1)
  • Pfam:PF00082 (1)
  • Pfam:PF09286 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tpp1-001 (1) 2054
    ncRNA tpp1-002 (1) 735
    mRNA tpp1-003 (1) 868
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-tpp1 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tpp1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    tpp1Contained in: [BAC] DKEY-230N6 (1) (order this)
    tpp1Encodes: [EST] fa01b09, IMAGE:7149243 (1) (order this)
    [cDNA] MGC:194849 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128798 (1) 1758bp
    Genomic GenBank:CR925704 (1) 99285bp
    Select Tool
    Polypeptide UniProtKB:F8W2M8 (1) 582aa
    Sequence Clusters UniGene:35596 (1)
    Sequence Information (all 16)
    OTHER tpp1 GENE PAGES
  • Gene:798347 (1)
  • VEGA:OTTDARG00000035050 (1)
  • Ensembl(GRCz10):ENSDARG00000042793 (1)
  • ORTHOLOGY for tpp1 (Chr: 17)
    Species Symbol Chromosome Accession # Evidence
    Human TPP1 11
  • Gene:1200
  • OMIM:607998
  • HGNC:2073
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (20)