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ZIRC
ZFIN ID: ZDB-GENE-030131-6654
Gene Name: tripeptidyl peptidase I
Gene Symbol: tpp1    Nomenclature History

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Previous Names: cln2, fa01b09, im:7149243, wu:fa01b09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have endopeptidase activity and tripeptidyl-peptidase activity. Involved in central nervous system development; locomotory behavior; and neurogenesis. Predicted to localize to the lysosome. Used to study neuronal ceroid lipofuscinosis 2. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 7 and neuronal ceroid lipofuscinosis 2. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and retinal neural layer. Orthologous to human TPP1 (tripeptidyl peptidase 1).
Genome Resources: Alliance (1),  Gene:798347 (1),  Ensembl(GRCz11):ENSDARG00000042793 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3587 Point Mutation Exon 11 Premature Stop ENU
sa11 Point Mutation Exon 3 Premature Stop ENU
sa2895 Point Mutation Unknown Splice Site ENU
sa6483 Point Mutation Unknown Premature Stop ENU
sa8389 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tpp1 N/A 1
    MO2-tpp1 N/A 1
    DISEASE ASSOCIATED WITH tpp1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive spinocerebellar ataxia 7 Alliance Spinocerebellar ataxia, autosomal recessive 7 609270
    neuronal ceroid lipofuscinosis 2 Alliance Ceroid lipofuscinosis, neuronal, 2 204500
    DISEASE ASSOCIATED WITH tpp1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    neuronal ceroid lipofuscinosis 2 tpp1sa11/sa11 standard conditions Mahmood et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system development (more)
    Cellular Component lysosome (more)
    Molecular Function tripeptidyl-peptidase activity (more)
    GO Terms (all 12)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tpp1-201 (1)    Ensembl 868
    tpp1-203 (1)    Ensembl 2054
    ncRNA tpp1-002 (1)    Ensembl 735
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tpp1 Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tpp1 No data available
    MARKER RELATIONSHIPS
    tpp1 Contained in: [BAC] DKEY-230N6 (1) (order this)
    tpp1 Encodes: [EST] fa01b09, IMAGE:7149243 (1) (order this)
    [cDNA] MGC:194849 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128798 (1) 1758 bp
    Genomic GenBank:BX546455 (1) 62516 bp
    Select Tool
    Polypeptide UniProtKB:A0A493VU28 (1) 582 aa
    Sequence Clusters UniGene:35596 (1)
    Sequence Information (all 18)
    ORTHOLOGY for tpp1 ( Chr: 17 )
    CITATIONS (30)