Gene

tpp1

ID
ZDB-GENE-030131-6654
Name
tripeptidyl peptidase I
Symbol
tpp1 Nomenclature History
Previous Names
  • cln2
  • fa01b09
  • im:7149243
  • wu:fa01b09
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have endopeptidase activity and tripeptidyl-peptidase activity. Involved in central nervous system development; locomotory behavior; and neurogenesis. Predicted to localize to lysosome. Used to study neuronal ceroid lipofuscinosis 2. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 7 and neuronal ceroid lipofuscinosis 2. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and retinal neural layer. Orthologous to human TPP1 (tripeptidyl peptidase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tpp1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 7 Alliance Spinocerebellar ataxia, autosomal recessive 7 609270
neuronal ceroid lipofuscinosis 2 Alliance Ceroid lipofuscinosis, neuronal, 2 204500
Associated With tpp1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000209 Peptidase S8/S53 domain
Domain IPR015366 Peptidase S53, activation domain
Domain IPR030400 Sedolisin domain
Homologous_superfamily IPR036852 Peptidase S8/S53 domain superfamily
Domain Details Per Protein
Protein Length Peptidase S53, activation domain Peptidase S8/S53 domain Peptidase S8/S53 domain superfamily Sedolisin domain
UniProtKB:A0A8M2B594 556
UniProtKB:F8W2M8 557
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tpp1 Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations