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ZIRC
ZFIN ID: ZDB-GENE-030131-6654
Gene Name: tripeptidyl peptidase I
Gene Symbol: tpp1
Sequence Ontology ID : SO:0000704

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Previous Names: cln2, fa01b09, im:7149243, wu:fa01b09

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(Including Attributions)
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have endopeptidase activity and tripeptidyl-peptidase activity. Involved in central nervous system development; locomotory behavior; and neurogenesis. Predicted to localize to the  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3587 Point Mutation Exon 11 Premature Stop ENU
sa11 Point Mutation Exon 3 Premature Stop ENU
sa2895 Point Mutation Unknown Splice Site ENU
sa6483 Point Mutation Unknown Premature Stop ENU
sa8389 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH tpp1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal recessive spinocerebellar ataxia 7 Spinocerebellar ataxia, autosomal recessive 7 609270
    neuronal ceroid lipofuscinosis 2 Ceroid lipofuscinosis, neuronal, 2 204500
    DISEASE ASSOCIATED WITH tpp1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    neuronal ceroid lipofuscinosis 2 tpp1sa11/sa11 standard conditions Mahmood et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system development (more)
    Cellular Component lysosome (more)
    Molecular Function tripeptidyl-peptidase activity (more)
    GO Terms (all 12)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA tpp1-002 (1) 735
    mRNA tpp1-201 (1) 868
    tpp1-203 (1) 2054
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tpp1 No data available
    MARKER RELATIONSHIPS
    tpp1Contained in: [BAC] DKEY-230N6 (1) (order this)
    tpp1Encodes: [EST] fa01b09, IMAGE:7149243 (1) (order this)
    [cDNA] MGC:194849 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128798 (1) 1758bp
    Genomic GenBank:BX546455 (1) 62516bp
    Select Tool
    Polypeptide UniProtKB:A0A493VU28 (1) 582aa
    Sequence Clusters UniGene:35596 (1)
    Sequence Information (all 18)
    ORTHOLOGY for tpp1 (Chr: 17)
    CITATIONS (29)