ZFIN ID: ZDB-GENE-030131-6654
Gene Name: tripeptidyl peptidase I
Gene Symbol: tpp1
Previous Names: cln2, fa01b09, im:7149243, wu:fa01b09
Location: Chr: 17   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7149243]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  retinal ganglion cell layer, retinal inner plexiform layer, retinal outer nuclear layer, unspecified
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 5 genotypes
Alleles: hu3587, sa11
Knockdown reagents: MO1-tpp1 (1), MO2-tpp1 (1)
PHENOTYPE
Data: 10 figures from 2 publications
Observed in: brain, caudal commissure axon, central nervous system, central nervous system projection neuron axonogenesis (all 24) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Ceroid lipofuscinosis, neuronal, 2 204500
Spinocerebellar ataxia, autosomal recessive 7 609270
GENE ONTOLOGY
Ontology GO Term
Biological Process central nervous system development (more)
Molecular Function tripeptidyl-peptidase activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000209 (1)
  • InterPro:IPR009020 (1)
  • InterPro:IPR015366 (1)
  • Pfam:PF00082 (1)
  • Pfam:PF09286 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tpp1-001 (1) 2054
    ncRNA tpp1-002 (1) 735
    mRNA tpp1-003 (1) 868
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-tpp1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tpp1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    tpp1 Contained in: [BAC] DKEY-230N6 (1)
    tpp1 Encodes: [EST] fa01b09, IMAGE:7149243 (1) (order this)
    [cDNA] MGC:194849 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128798 (1) 1758 bp
    Genomic GenBank:CR925704 (1) 99285 bp
    Select Tool
    Polypeptide UniProtKB:F8W2M8 (1) 582 aa
    Sequence Clusters UniGene:35596 (1)
    Sequence Information (all 17)
    OTHER tpp1 GENE PAGES
  • Gene:798347 (1)
  • VEGA:OTTDARG00000035050 (1)
  • Ensembl(Zv9):ENSDARG00000042793 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish tpp1 17  
    Human TPP1 11 (11p15)
  • OMIM:607998
  • Gene:1200
  • Orthology Details
    CITATIONS (18)