ZFIN ID: ZDB-GENE-030131-6654
Gene Name: tripeptidyl peptidase I
Gene Symbol: tpp1
Previous Names: cln2, fa01b09, im:7149243, wu:fa01b09
Location: Chr: 17   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7149243]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  retinal ganglion cell layer, retinal inner plexiform layer, retinal outer nuclear layer, unspecified
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 5 Genotypes
Knockdown reagents: MO1-tpp1 (1), MO2-tpp1 (1)

Allele Type Mutagen Suppliers
hu3587 Point Mutation ENU
sa11 Point Mutation ENU
PHENOTYPE
Data: 10 figures from 2 publications
Observed in: brain, caudal commissure axon, central nervous system, central nervous system projection neuron axonogenesis (all 24) expand
DISEASE ASSOCIATED WITH tpp1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
neuronal ceroid lipofuscinosis Ceroid lipofuscinosis, neuronal, 2 204500
Spinocerebellar ataxia, autosomal recessive 7 609270
GENE ONTOLOGY
Ontology GO Term
Biological Process central nervous system development (more)
Molecular Function tripeptidyl-peptidase activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000209 (1)
  • InterPro:IPR009020 (1)
  • InterPro:IPR015366 (1)
  • InterPro:IPR030400 (1)
  • PROSITE:PS51695 (1)
  • Pfam:PF00082 (1)
  • Pfam:PF09286 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tpp1-001 (1) 2054
    ncRNA tpp1-002 (1) 735
    mRNA tpp1-003 (1) 868
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-tpp1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tpp1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    tpp1 Contained in: [BAC] DKEY-230N6 (1) (order this)
    tpp1 Encodes: [EST] fa01b09, IMAGE:7149243 (1) (order this)
    [cDNA] MGC:194849 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128798 (1) 1758 bp
    Genomic GenBank:CR925704 (1) 99285 bp
    Select Tool
    Polypeptide UniProtKB:F8W2M8 (1) 582 aa
    Sequence Clusters UniGene:35596 (1)
    Sequence Information (all 17)
    OTHER tpp1 GENE PAGES
  • Gene:798347 (1)
  • VEGA:OTTDARG00000035050 (1)
  • Ensembl(Zv9):ENSDARG00000042793 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish tpp1 17  
    Human TPP1 11 (11p15)
  • OMIM:607998
  • Gene:1200
  • Orthology Details
    CITATIONS (19)