ZFIN ID: ZDB-GENE-030131-6493
Gene Name: acyl-CoA synthetase long chain family member 4b
Gene Symbol: acsl4b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: acsl4l, si:dkeyp-20g2.4 (1), wu:fl49b07 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have arachidonate-CoA ligase activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Predicted to localize to endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including digestive system; hatching gland; heart; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4).
Genome Resources: Alliance (1),  Gene:334561 (1),  Ensembl(GRCz11):ENSDARG00000010752 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (13 images) from Thisse et al., 2004 [IMAGE:7147969]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa25296 Point Mutation Unknown Premature Stop ENU
sa31432 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44604 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH acsl4b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    non-syndromic X-linked intellectual disability Alliance Mental retardation, X-linked 63 300387
    DISEASE ASSOCIATED WITH acsl4b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Molecular Function catalytic activity (more)
    GO Terms (all 1)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acsl4b-201 (1)    Ensembl 3641
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acsl4b No data available
    MARKER RELATIONSHIPS
    acsl4b Contained in: [BAC] DKEYP-20G2 (1)
    acsl4b Encodes: [EST] fl49b07, IMAGE:7147969 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001099739 (1)
    Genomic GenBank:CR926467 (1) 153796 nt
    Select Tool
    Polypeptide UniProtKB:Q58EE3 (1) 691 aa
    Sequence Information (all 17)
    ORTHOLOGY for acsl4b ( Chr: 5 )
    CITATIONS (21)