Gene

acsl4b

ID
ZDB-GENE-030131-6493
Name
acyl-CoA synthetase long chain family member 4b
Symbol
acsl4b Nomenclature History
Previous Names
  • acsl4l
  • si:dkeyp-20g2.4 (1)
  • wu:fl49b07 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have arachidonate-CoA ligase activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Predicted to localize to endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including digestive system; hatching gland; heart; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acsl4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability Alliance Mental retardation, X-linked 63 300387
Associated With acsl4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020845 AMP-binding, conserved site
Domain IPR000873 AMP-dependent synthetase/ligase
Homologous_superfamily IPR042099 AMP-dependent synthetase-like superfamily
Domain Details Per Protein
Protein Length AMP-binding, conserved site AMP-dependent synthetase/ligase AMP-dependent synthetase-like superfamily
UniProtKB:A5WV16 671
UniProtKB:Q7SXQ9 688
UniProtKB:Q58EE3 691
UniProtKB:Q08CP5 654
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Orthology Note
Woods, et al. (2005. Genome Res. 15:1307-1914.) reported orthology to ACSL4 supported by amino acid sequence identity and conserved location.
Citations