ZFIN ID: ZDB-GENE-030131-6070
Gene Name: nipped-B homolog b (Drosophila)
Gene Symbol: nipblb

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Previous Names: nipbl (1), fc12g03, wu:fc12g03, wu:fi33d08 (1)

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(Including Attributions)
Location: Chr: 10 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Wild-type Stages, Structures: Blastula:512-cell (2.75h-3.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
  blastoderm, blastodisc, central nervous system, diencephalon (all 12) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027180Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7339 Point Mutation Unknown Nonsynonymous ENU
    sa8848 Point Mutation Unknown Premature Stop ENU
    sa10463 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17819 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa18992 Point Mutation Unknown Premature Stop ENU
    sa30653 Point Mutation Unknown Premature Stop ENU
    sa31792 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34952 Point Mutation Unknown Splice Site, Nonsynonymous ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38808 Point Mutation Unknown Splice Site ENU
    sa38809 Point Mutation Unknown Premature Stop ENU
    sa41708 Point Mutation Unknown Premature Stop ENU
    sa41709 Point Mutation Unknown Premature Stop ENU
    sa41710 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-nipblb (1), MO2-nipblb (1), MO3-nipblb (1)
    PHENOTYPE
    Data: 5 figures from 2 publications
    Observed in: apoptotic process, brain, cell proliferation, central nervous system development (all 10) expand
    DISEASE ASSOCIATED WITH nipblb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Cornelia de Lange syndrome Cornelia de Lange syndrome 1 122470
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process developmental growth (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011989 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR024986 (1)
  • InterPro:IPR026003 (1)
  • InterPro:IPR033031 (1)
  • Pfam:PF12765 (1)
  • Pfam:PF12830 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nipblb-001 (1) 9367
    ncRNA nipblb-002 (1) 753
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-nipblb (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nipblb No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    nipblbContained in: [BAC] CH211-135J7 (1) (order this), DKEY-21N12 (1) (order this)
    nipblbEncodes: [EST] fc12g03, fi33d08
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001161447 (1) 9738bp
    Genomic GenBank:AL929053 (1) 142345bp
    Select Tool
    Polypeptide UniProtKB:F1QBY1 (1) 2876aa
    Sequence Clusters UniGene:78039 (1)
    Sequence Information (all 18)
    OTHER nipblb GENE PAGES
  • Gene:794108 (1)
  • VEGA:OTTDARG00000031185 (1)
  • Ensembl(GRCz10):ENSDARG00000061052 (1)
  • ORTHOLOGY for nipblb (Chr: 10)
    Species Symbol Chromosome Accession # Evidence
    Human NIPBL 5
  • Gene:25836
  • OMIM:608667
  • HGNC:28862
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Mouse Nipbl 15
  • MGI:1913976
  • Gene:71175
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (23)