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ZIRC
ZFIN ID: ZDB-GENE-030131-5906
Gene Name: glutamate-cysteine ligase, modifier subunit
Gene Symbol: gclm    Nomenclature History

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Previous Names: GLCLR (1), id:ibd3182, wu:fi24c07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have enzyme regulator activity. Predicted to be involved in glutathione biosynthetic process and positive regulation of glutamate-cysteine ligase activity. Predicted to localize to the glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Is expressed in several structures, including brain; germ ring; immature eye; liver; and pronephric duct. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit).
Genome Resources: Alliance (1),  Gene:333974 (1),  Ensembl(GRCz11):ENSDARG00000018953 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH gclm HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Myocardial infarction, susceptibility to} 608446
DISEASE ASSOCIATED WITH gclm VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process glutathione biosynthetic process (more)
Cellular Component glutamate-cysteine ligase complex (more)
Molecular Function glutamate-cysteine ligase catalytic subunit binding (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR032963 (1)
  • InterPro:IPR036812 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gclm-201 (1)    Ensembl 1826
    ncRNA gclm-002 (1) 525
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gclm No data available
    MARKER RELATIONSHIPS
    gclm Contained in: [BAC] DKEY-7O6 (1) (order this)
    gclm Contains: [SNP] rs3728145 (1), rs3728146 (1)
    gclm Encodes: [EST] fi24c07, ibd3182 (1) (order this), IMAGE:6907712 (1) (order this)
    [cDNA] MGC:55903 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199845 (1) 1844 bp
    Genomic GenBank:BX005425 (1) 252440 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A8WHP4 (1) 273 aa
    Sequence Clusters UniGene:80559 (1)
    Sequence Information (all 16)
    ORTHOLOGY for gclm ( Chr: 8 )
    CITATIONS (37)