Gene
gclm
- ID
- ZDB-GENE-030131-5906
- Name
- glutamate-cysteine ligase, modifier subunit
- Symbol
- gclm Nomenclature History
- Previous Names
-
- GLCLR (1)
- id:ibd3182
- wu:fi24c07
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have enzyme regulator activity. Predicted to be involved in glutathione biosynthetic process and positive regulation of glutamate-cysteine ligase activity. Predicted to localize to glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Is expressed in several structures, including brain; germ ring; immature eye; liver; and pronephric duct. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907712 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Myocardial infarction, susceptibility to} | 608446 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glutamate--cysteine ligase regulatory subunit | NADP-dependent oxidoreductase domain | NADP-dependent oxidoreductase domain superfamily |
|---|---|---|---|---|
|
UniProtKB:A0A8M3AUZ9
|
274 | |||
|
UniProtKB:Q803D0
|
273 |
Interactions and Pathways
No data available
Plasmids
No data available