Gene

gclm

ID
ZDB-GENE-030131-5906
Name
glutamate-cysteine ligase, modifier subunit
Symbol
gclm Nomenclature History
Previous Names
  • GLCLR (1)
  • id:ibd3182
  • wu:fi24c07
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have enzyme regulator activity. Predicted to be involved in glutathione biosynthetic process and positive regulation of glutamate-cysteine ligase activity. Predicted to localize to glutamate-cysteine ligase complex. Is expressed in several structures, including brain; germ ring; immature eye; liver; and pronephric duct. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gclm Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Myocardial infarction, susceptibility to} 608446
Associated With gclm Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR032963 Glutamate--cysteine ligase regulatory subunit
Homologous_superfamily IPR036812 NADP-dependent oxidoreductase domain superfamily
Domain Details Per Protein
Protein Length Glutamate--cysteine ligase regulatory subunit NADP-dependent oxidoreductase domain superfamily
UniProtKB:A8WHP4 273
UniProtKB:Q803D0 273
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations