ZFIN ID: ZDB-GENE-030131-5870
Gene Name: myosin, heavy chain 9a, non-muscle
Gene Symbol: myh9a    Nomenclature History

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Previous Names: myh9, myh9l2, fi22c04, fj85e11, wu:fi22c04 (1), wu:fj85e11, zgc:162029 (1), zNMHC-IIA (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to myosin complex. Is expressed in several structures, including epidermis; nervous system; periderm; pronephric duct opening; and tail bud. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and proteinuria. Orthologous to human MYH9 (myosin heavy chain 9).
Genome Resources: Alliance (1),  Gene:333938 (1),  Ensembl(GRCz11):ENSDARG00000063295 (2)
DISEASE ASSOCIATED WITH myh9a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 17 Alliance Deafness, autosomal dominant 17 603622
MYH-9 related disease Alliance Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss 155100
DISEASE ASSOCIATED WITH myh9a VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
kidney disease AB/EKW + MO1-myh9a standard conditions Anderson et al., 2015
GENE ONTOLOGY
Ontology GO Term
Biological Process glomerular filtration (more)
Cellular Component myosin complex (more)
Molecular Function actin binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA myh9a-202 (1)    Ensembl 6842
ncRNA myh9a-002 (1)    Ensembl 791
Browsers: UCSCEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-myh9 polyclonal Rabbit IHC, WB Covance
4
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM myh9a No data available
MARKER RELATIONSHIPS
myh9a Contained in: [BAC] CH211-215G15 (1)
myh9a Encodes: [EST] fi22c04, fj85e11
[cDNA] MGC:66164 (1), MGC:162029 (1), MGC:165368 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001098177 (1) 3050 nt
Genomic GenBank:CR925711 (1) 200688 nt Blast at MegaBLAST
Polypeptide UniProtKB:F8W3L6 (1) 1964 aa
Sequence Information (all 43)
ORTHOLOGY for myh9a ( Chr: 6 )
CITATIONS (44)