ZFIN ID: ZDB-GENE-030131-577
Gene Name: pre-mRNA processing factor 8
Gene Symbol: prpf8    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: id:ibd1257, ik:tdsubc_2a9 (1), im:7141966 (1), tdsubc_2a9, wu:fb37c02, wu:fb73e06, xx:tdsubc_2a9, zgc:56504

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have pre-mRNA intronic binding activity and snRNA binding activity. Involved in spliceosomal tri-snRNP complex assembly. Predicted to localize to U5 snRNP and catalytic step 2 spliceosome. Is expressed in brain. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 13. Orthologous to human PRPF8 (pre-mRNA processing factor 8).
Genome Resources: Alliance (1),  Gene:393951 (1),  Ensembl(GRCz11):ENSDARG00000026180 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Kudoh et al., 2001 [ibd1257]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7141966]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7137198]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gl1 Point Mutation Exon 8 Premature Stop ENU
la019288Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1289 Point Mutation Unknown Premature Stop ENU
    sa2823 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-prpf8 N/A 1
    MO2-prpf8 N/A 1
    DISEASE ASSOCIATED WITH prpf8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    retinitis pigmentosa 13 Alliance Retinitis pigmentosa 13 600059
    DISEASE ASSOCIATED WITH prpf8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process spliceosomal tri-snRNP complex assembly (more)
    Cellular Component nucleus (more)
    Molecular Function isopeptidase activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prpf8-201 (1)    Ensembl 7534
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prpf8 No data available
    MARKER RELATIONSHIPS
    prpf8 Contained in: [BAC] CH211-209M4 (1)
    prpf8 Contains: [SNP] rs3728726 (1), rs3728727 (1), rs3728728 (1)
    prpf8 Encodes: [EST] fb37c02, fb73e06, ibd1257, IMAGE:7137198 (1), IMAGE:7141966 (1), tdsubc_2a9
    [cDNA] MGC:162871 (1)
    prpf8 Has Artifact: [cDNA] MGC:56504
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200976 (1) 7541 nt
    Genomic GenBank:CR522882 (1) 129430 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4J8E6 (1) 2342 aa
    Sequence Information (all 18)
    ORTHOLOGY for prpf8 ( Chr: 15 )
    CITATIONS (33)