ZFIN ID: ZDB-GENE-030131-577 |
Gene Name: | pre-mRNA processing factor 8 | ||||||
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Gene Symbol: | prpf8 Nomenclature History | ||||||
Previous Names: | id:ibd1257, ik:tdsubc_2a9 (1), im:7141966 (1), tdsubc_2a9, wu:fb37c02, wu:fb73e06, xx:tdsubc_2a9, zgc:56504 | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Chr: 15 Mapping Details/Browsers | ||||||
Description: | Predicted to have pre-mRNA intronic binding activity; second spliceosomal transesterification activity; and snRNA binding activity. Involved in spliceosomal tri-snRNP complex assembly. Predicted to localize to the U5 snRNP and catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 13. Is expressed in brain. Orthologous to human PRPF8 (pre-mRNA processing factor 8). | ||||||
Genome Resources: | Alliance (1), Gene:393951 (1), Ensembl(GRCz11):ENSDARG00000026180 (2) |
All Expression Data: | 4 figures from 3 publications |
Directly Submitted Expression Data: | 1 figure (1 image) from Kudoh et al., 2001 [ibd1257] |
1 figure (1 image) from Thisse et al., 2004 [IMAGE:7141966] | |
1 figure (1 image) from Thisse et al., 2004 [IMAGE:7137198] | |
Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h) |
Curated Microarray Expression: | GEO (1) |
Allele | Type | Localization | Consequence | Mutagen | Suppliers |
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gl1 | Point Mutation | Exon 8 | Premature Stop | ENU | |
la019288Tg | Transgenic Insertion | Unknown | Unknown | DNA |
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sa1289 | Point Mutation | Unknown | Premature Stop | ENU | |
sa2823 | Point Mutation | Unknown | Premature Stop | ENU |
Data: | 3 figures from Keightley et al., 2013 |
Observed in: |
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
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retinitis pigmentosa 13 | Alliance | Retinitis pigmentosa 13 | 600059 |
Ontology | GO Term |
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Biological Process | spliceosomal tri-snRNP complex assembly (more) |
Cellular Component | spliceosomal complex (more) |
Molecular Function | RNA binding (more) |
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Type | Name | Length (nt) | Analysis | |
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mRNA |
prpf8-201
(1)
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7534 |
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Browsers: UCSC, NCBI, Ensembl, ZFIN |
prpf8 Contained in: | [BAC] CH211-209M4 (1) (order this) |
prpf8 Contains: | [SNP] rs3728726 (1), rs3728727 (1), rs3728728 (1) |
prpf8 Encodes: |
[EST]
fb37c02,
fb73e06,
ibd1257 (order this),
IMAGE:7137198 (1) (order this),
IMAGE:7141966 (1) (order this),
tdsubc_2a9
[cDNA] MGC:162871 (1) (order this) |
prpf8 Has Artifact: | [cDNA] MGC:56504 (order this) |
Type | Accession # | Length (bp/aa) | Analysis |
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RNA | RefSeq:NM_200976 (1) | 7541 bp |
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Genomic | GenBank:CR522882 (1) | 129430 bp | |
Polypeptide | UniProtKB:A0A0R4J8E6 (1) | 2342 aa |
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Sequence Clusters | UniGene:45839 (1) |