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ZFIN ID: ZDB-GENE-030131-577
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Gene Name: pre-mRNA processing factor 8
Gene Symbol: prpf8    Nomenclature History

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Previous Names: id:ibd1257, ik:tdsubc_2a9 (1), im:7141966 (1), tdsubc_2a9, wu:fb37c02, wu:fb73e06, xx:tdsubc_2a9, zgc:56504

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Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have pre-mRNA intronic binding activity; second spliceosomal transesterification activity; and snRNA binding activity. Involved in spliceosomal tri-snRNP complex assembly. Predicted to localize to the U5 snRNP and catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 13. Is expressed in brain. Orthologous to human PRPF8 (pre-mRNA processing factor 8).
Genome Resources: Alliance (1),  Gene:393951 (1),  Ensembl(GRCz11):ENSDARG00000026180 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Kudoh et al., 2001 [ibd1257]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7141966]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7137198]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gl1 Point Mutation Exon 8 Premature Stop ENU
la019288Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa1289 Point Mutation Unknown Premature Stop ENU
    sa2823 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-prpf8 N/A 1
    MO2-prpf8 N/A 1
    PHENOTYPE
    Data: 3 figures from Keightley et al., 2013
    Observed in:
    DISEASE ASSOCIATED WITH prpf8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    retinitis pigmentosa 13 Alliance Retinitis pigmentosa 13 600059
    DISEASE ASSOCIATED WITH prpf8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process spliceosomal tri-snRNP complex assembly (more)
    Cellular Component spliceosomal complex (more)
    Molecular Function RNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000555 (1)
  • InterPro:IPR012337 (1)
  • InterPro:IPR012591 (1)
  • InterPro:IPR012592 (1)
  • InterPro:IPR012984 (1)
  • InterPro:IPR019580 (1)
  • InterPro:IPR019581 (1)
  • InterPro:IPR019582 (1)
  • InterPro:IPR021983 (1)
  • InterPro:IPR027652 (1)
  • InterPro:IPR037518 (1)
  • InterPro:IPR042516 (1)
  • PROSITE:PS50249 (1)
  • Pfam:PF01398 (1)
  • Pfam:PF08082 (1)
  • Pfam:PF08083 (1)
  • Pfam:PF08084 (1)
  • Pfam:PF10596 (1)
  • Pfam:PF10597 (1)
  • Pfam:PF10598 (1)
  • Pfam:PF12134 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prpf8-201 (1)    Ensembl 7534
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prpf8 No data available
    MARKER RELATIONSHIPS
    prpf8 Contained in: [BAC] CH211-209M4 (1) (order this)
    prpf8 Contains: [SNP] rs3728726 (1), rs3728727 (1), rs3728728 (1)
    prpf8 Encodes: [EST] fb37c02, fb73e06, ibd1257 (order this), IMAGE:7137198 (1) (order this), IMAGE:7141966 (1) (order this), tdsubc_2a9
    [cDNA] MGC:162871 (1) (order this)
    prpf8 Has Artifact: [cDNA] MGC:56504 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200976 (1) 7541 bp
    Select Tool
    Genomic GenBank:CR522882 (1) 129430 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4J8E6 (1) 2342 aa
    Select Tool
    Sequence Clusters UniGene:45839 (1)
    Sequence Information (all 19)
    ORTHOLOGY for prpf8 ( Chr: 15 )
    CITATIONS (31)