ZFIN ID: ZDB-GENE-030131-574
Gene Name: intraflagellar transport 88 homolog
Gene Symbol: ift88    Nomenclature History

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Previous Names: ovl, fb37b11, intraflagellar transport protein 88 (1), oval, polaris (1), ttc10 (1), wu:fb37b11, xx:zah8127

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have kinesin binding activity. Involved in several processes, including cilium organization; neuron development; and tissue homeostasis. Localizes to the axoneme and ciliary basal body. Is expressed in forerunner cell group; head; nervous system; and pronephric duct. Orthologous to human IFT88 (intraflagellar transport 88).
Genome Resources: Alliance (1),  Gene:321855 (1),  Ensembl(GRCz11):ENSDARG00000027234 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ift88_unspecified Unspecified Unknown Unknown
sa7628 Point Mutation Unknown Missense ENU
sa8799 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18944 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27381 Point Mutation Unknown Premature Stop ENU
    sa41401 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tz288 Point Mutation Exon 11 Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ift88
    1
    CRISPR2-ift88
    1
    CRISPR3-ift88
    1
    MO1-ift88 N/A 11
    MO2-ift88 N/A 5
    MO3-ift88 N/A 7
    MO4-ift88 N/A 6
    MO5-ift88 N/A 1
    MO6-ift88 N/A 1
    MO7-ift88 N/A 1
    PHENOTYPE
    Data: 42 figures from 27 publications
    Observed in:
    DISEASE ASSOCIATED WITH ift88 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ift88 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component axoneme (more)
    Molecular Function kinesin binding (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
    Domain IPR013026 Tetratricopeptide repeat-containing domain
    Repeat IPR019734 Tetratricopeptide repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ift88-201 (1)    Ensembl 2941
    ift88-203 (1)    Ensembl 602
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-ift88 Rabbit IHC 1
    Ab1-ift88 polyclonal Rabbit IHC, WB 13
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ift88 No data available
    MARKER RELATIONSHIPS
    ift88 Contained in: [BAC] DKEY-51D17 (1) (order this)
    ift88 Encodes: [EST] fb37b11, zah8127
    [cDNA] MGC:193654 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001001725 (1) 2897 bp
    Genomic GenBank:CR392366 (1) 125898 bp
    Select Tool
    Polypeptide UniProtKB:F1QVN7 (1) 855 aa
    Sequence Information (all 43)
    ORTHOLOGY for ift88 ( Chr: 9 )
    CITATIONS (93)