ZFIN ID: ZDB-GENE-030131-5628
Gene Name: hydroxysteroid (17-beta) dehydrogenase 12a
Gene Symbol: hsd17b12a    Nomenclature History

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Previous Names: fi06g11, zf 3.1 (1), wu:fi06g11, zgc:55589

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have estradiol 17-beta-dehydrogenase activity. Predicted to be involved in estrogen biosynthetic process; fatty acid biosynthetic process; and oxidation-reduction process. Predicted to localize to endoplasmic reticulum; endoplasmic reticulum membrane; and integral component of membrane. Is expressed in several structures, including EVL; digestive system; integument; nervous system; and pleuroperitoneal region. Orthologous to human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).
Genome Resources: Alliance (1),  Gene:327417 (1),  Ensembl(GRCz11):ENSDARG00000015709 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [MGC:55589]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb364 Small Deletion Unknown Unknown CRISPR
ihb365 Insertion Unknown Unknown CRISPR
sa3308 Point Mutation Unknown Splice Site ENU
sa32541 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hsd17b12a 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hsd17b12a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hsd17b12a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process estrogen biosynthetic process (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function estradiol 17-beta-dehydrogenase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hsd17b12a-201 (1)    Ensembl 2012
    ncRNA hsd17b12a-002 (1)    Ensembl 755
    hsd17b12a-003 (1)    Ensembl 885
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hsd17b12a No data available
    MARKER RELATIONSHIPS
    hsd17b12a Contained in: [BAC] CH211-147K10 (1)
    hsd17b12a Encodes: [EST] fi06g11
    [cDNA] MGC:55589 (1), MGC:77599 (1), MGC:191520 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200881 (1) 2031 nt
    Genomic GenBank:CR376745 (1) 186587 nt
    Select Tool
    Polypeptide UniProtKB:B2GPH2 (1) 319 aa
    Sequence Information (all 21)
    ORTHOLOGY for hsd17b12a ( Chr: 25 )
    CITATIONS (29)