ZFIN ID: ZDB-GENE-030131-5626
Gene Name: potassium voltage-gated channel, Shal-related subfamily, member 3
Gene Symbol: kcnd3    Nomenclature History

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Previous Names: wu:fi06g01, zgc:55306, zShal3 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits voltage-gated potassium channel activity. Predicted to contribute to A-type (transient outward) potassium channel activity. Predicted to be involved in potassium ion export across plasma membrane. Predicted to localize to dendrite; neuronal cell body; and voltage-gated potassium channel complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3).
Genome Resources: Alliance (1),  Gene:327415 (1),  Ensembl(GRCz11):ENSDARG00000056101 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Directly Submitted Expression Data: 3 figures (4 images) from Thisse et al., 2004 [MGC:55306]
Wild-type Stages, Structures: Pharyngula:Prim-15 (30.0h-36.0h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016331Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029466Tg Transgenic Insertion Unknown Unknown DNA
    sa21312 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34425 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44688 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kcnd3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Brugada syndrome 9 Alliance Brugada syndrome 9 616399
    spinocerebellar ataxia type 19/22 Alliance Spinocerebellar ataxia 19 607346
    DISEASE ASSOCIATED WITH kcnd3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function voltage-gated potassium channel activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kcnd3-201 (1)    Ensembl 3065
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kcnd3 No data available
    MARKER RELATIONSHIPS
    kcnd3 Contained in: [BAC] CH211-198G1 (1), DKEY-193L3 (1) (order this)
    kcnd3 Encodes: [EST] fi06g01
    [cDNA] MGC:55306 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199802 (1) 3056 nt
    Genomic GenBank:BX664742 (1) 215608 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A286Y962 (1) 650 aa
    Sequence Information (all 18)
    ORTHOLOGY for kcnd3 ( Chr: 8 )
    CITATIONS (27)