Gene

kcnd3

ID
ZDB-GENE-030131-5626
Name
potassium voltage-gated channel, Shal-related subfamily, member 3
Symbol
kcnd3 Nomenclature History
Previous Names
  • wu:fi06g01
  • zgc:55306
  • zShal3 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Exhibits voltage-gated potassium channel activity. Predicted to be involved in potassium ion export across plasma membrane. Predicted to localize to several cellular components, including dendritic spine; postsynaptic density; and voltage-gated potassium channel complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnd3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Brugada syndrome 9 Alliance Brugada syndrome 9 616399
spinocerebellar ataxia type 19/22 Alliance Spinocerebellar ataxia 19 607346
Associated With kcnd3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000210 BTB/POZ domain
Domain IPR003131 Potassium channel tetramerisation-type BTB domain
Domain IPR005821 Ion transport domain
Domain IPR021645 Shal-type voltage-gated potassium channels, N-terminal
Domain IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
Family IPR003968 Potassium channel, voltage dependent, Kv
Family IPR003975 Potassium channel, voltage dependent, Kv4
Family IPR004056 Potassium channel, voltage dependent, Kv4.3
Family IPR028325 Voltage-gated potassium channel
Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Domain Details Per Protein
Protein Length BTB/POZ domain Ion transport domain Potassium channel tetramerisation-type BTB domain Potassium channel, voltage dependent, Kv Potassium channel, voltage dependent, Kv4 Potassium channel, voltage dependent, Kv4.3 Potassium channel, voltage dependent, Kv4, C-terminal Shal-type voltage-gated potassium channels, N-terminal SKP1/BTB/POZ domain superfamily Voltage-dependent channel domain superfamily Voltage-gated potassium channel
UniProtKB:Q7ZW36 638
UniProtKB:A0A286Y962 650
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations