Gene
taf1
- ID
- ZDB-GENE-030131-5576
- Name
- TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor
- Symbol
- taf1 Nomenclature History
- Previous Names
-
- wu:fi04f03
- wu:fy39f07
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have TBP-class protein binding activity; histone acetyltransferase activity; and sequence-specific DNA binding activity. Involved in developmental growth and midbrain development. Predicted to localize to transcription factor TFIID complex. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to several human genes including TAF1 (TATA-box binding protein associated factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898986 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| X-linked dystonia-parkinsonism | Alliance | Dystonia-Parkinsonism, X-linked | 314250 |
| Intellectual developmental disorder, X-linked syndromic 33 | 300966 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR009067 | TAFII-230 TBP-binding |
| Domain | IPR022591 | Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain |
| Domain | IPR041670 | Zinc knuckle |
| Family | IPR011177 | Transcription initiation factor TFIID subunit 1, animal |
| Family | IPR040240 | Transcription initiation factor TFIID subunit 1 |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR036741 | TAFII-230 TBP-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Bromodomain | Bromodomain, conserved site | Bromodomain-like superfamily | TAFII-230 TBP-binding | TAFII-230 TBP-binding domain superfamily | Transcription initiation factor TFIID subunit 1 | Transcription initiation factor TFIID subunit 1, animal | Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain | Zinc knuckle |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QDY7
|
1982 | |||||||||
|
UniProtKB:A0A8M9Q8M9
|
1971 | |||||||||
|
UniProtKB:A0A8M9Q3C1
|
1984 | |||||||||
|
UniProtKB:Q1LYC2
|
1947 | |||||||||
|
UniProtKB:A0A8M2BCS6
|
1949 |
Interactions and Pathways
No data available
Plasmids
No data available