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ZIRC
ZFIN ID: ZDB-GENE-030131-556
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Gene Name: kelch-like ECH-associated protein 1a
Gene Symbol: keap1a    Nomenclature History

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Previous Names: keap1, klhl19 (1), wu:fb36f11 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Involved in cellular response to prostaglandin stimulus and cellular response to xenobiotic stimulus. Human ortholog(s) of this gene implicated in gallbladder cancer. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Orthologous to human KEAP1 (kelch like ECH associated protein 1).
Genome Resources: Alliance (1),  Gene:321837 (1),  Ensembl(GRCz11):ENSDARG00000016132 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12803 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH keap1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH keap1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to prostaglandin stimulus (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000210 (1)
  • InterPro:IPR006652 (1)
  • InterPro:IPR011333 (1)
  • InterPro:IPR011705 (1)
  • InterPro:IPR015915 (1)
  • InterPro:IPR017096 (1)
  • PROSITE:PS50097 (1)
  • Pfam:PF00651 (1)
  • Pfam:PF01344 (1)
  • Pfam:PF07707 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA keap1a-201 (1)    Ensembl 2868
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM keap1a No data available
    MARKER RELATIONSHIPS
    keap1a Contained in: [BAC] CH211-107E10 (1) (order this), DKEY-97A13 (1) (order this)
    keap1a Encodes: [EST] fb36f11
    [cDNA] MGC:136521 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_182864 (1) 2888 bp
    Select Tool
    Genomic GenBank:BX663525 (1) 261927 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q1ECZ2 (1) 601 aa
    Select Tool
    Sequence Clusters UniGene:52260 (1)
    Sequence Information (all 16)
    ORTHOLOGY for keap1a ( Chr: 2 )
    CITATIONS (47)