ZFIN ID: ZDB-GENE-030131-5344
Gene Name: hypoxia up-regulated 1
Gene Symbol: hyou1    Nomenclature History

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Previous Names: id:ibd5056, wu:fd14c05, zgc:56019

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have ATP binding activity. Predicted to be involved in cellular response to hypoxia and negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. Predicted to localize to endoplasmic reticulum chaperone complex. Is expressed in several structures, including anterior axial hypoblast; digestive system; hatching gland; immature eye; and polster. Orthologous to human HYOU1 (hypoxia up-regulated 1).
Genome Resources: Alliance (1),  Gene:327133 (1),  Ensembl(GRCz11):ENSDARG00000013670 (2)
GENE EXPRESSION
All Expression Data: 12 figures from 3 publications
Directly Submitted Expression Data: 3 figures (5 images) from Kudoh et al., 2001 [ibd5056]
  4 figures (3 images) from Thisse et al., 2004 [IMAGE:7141613]
  4 figures (5 images) from Thisse et al., 2004 [IMAGE:6895638]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011843Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027168Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30941 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41684 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hyou1
    2
    CRISPR2-hyou1
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hyou1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Immunodeficiency 59 and hypoglycemia 233600
    DISEASE ASSOCIATED WITH hyou1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to hypoxia (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function ATP binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hyou1-201 (1)    Ensembl 3959
    ncRNA hyou1-002 (1)    Ensembl 734
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hyou1 No data available
    MARKER RELATIONSHIPS
    hyou1 Contained in: [BAC] CH73-261I21 (1)
    hyou1 Contains: [SNP] rs3728318 (1), rs3728319 (1), rs3728320 (1), rs3728321 (1)
    hyou1 Encodes: [EST] fd14c05, ibd5056 (1), IMAGE:6895638 (1), IMAGE:7141613 (1)
    [cDNA] MGC:56019 (1), MGC:192405 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212703 (1) 3862 nt
    Genomic GenBank:CU861448 (1) 106257 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QLL5 (1) 1003 aa
    Sequence Information (all 26)
    ORTHOLOGY for hyou1 ( Chr: 10 )
    CITATIONS (38)