Gene

cpsf6

ID

ZDB-GENE-030131-5277

Name

cleavage and polyadenylation specific factor 6

Symbol

cpsf6 Nomenclature History

Previous Names

wu:fa22f12
zgc:85819 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have mRNA binding activity. Predicted to be involved in mRNA alternative polyadenylation; positive regulation of RNA export from nucleus; and protein-containing complex assembly. Predicted to localize to cytoplasm; mRNA cleavage factor complex; and nuclear lumen. Is expressed in several structures, including blastomere; central nervous system; digestive system; eye; and yolk. Orthologous to human CPSF6 (cleavage and polyadenylation specific factor 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

MGC:85819 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cpsf6 Human Ortholog

No data available

Associated With cpsf6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Family	IPR034769	Cleavage and polyadenylation specificity factor subunit 6
Family	IPR034772	CPSF6/7 family
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Cleavage and polyadenylation specificity factor subunit 6	CPSF6/7 family	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA recognition motif domain
UniProtKB:Q6NWC6 InterPro	545
UniProtKB:Q1L8Q3 InterPro	117
UniProtKB:A0A2R8RIN6 InterPro	571
UniProtKB:H0WFE8 InterPro	127

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	cpsf6-201 (1) Ensembl	2205 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cpsf6-202 (1) Ensembl	2160 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cpsf6-203 (1) Ensembl	813 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cpsf6-205 (1) Ensembl	900 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cpsf6-004 (1) Ensembl	797 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-cpsf6	monoclonal	cpsf6	IgG2a , k	Mouse		Santa Cruz Biotechnology, Inc.	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations