ZFIN ID: ZDB-GENE-030131-5213
Gene Name: ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)
Gene Symbol: arih1    Nomenclature History

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Previous Names: wu:fa18d01, zgc:66364

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to colocalize with the cullin-RING ubiquitin ligase complex. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1).
Genome Resources: Alliance (1),  Gene:327005 (1),  Ensembl(GRCz11):ENSDARG00000003616 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66364]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43081 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH arih1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH arih1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein ubiquitination (more)
    Cellular Component COLOCALIZES_WITH   Cul2-RING ubiquitin ligase complex (more)
    Molecular Function ubiquitin-protein transferase activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001841 Zinc finger, RING-type
    Domain IPR002867 IBR domain
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    Family IPR031127 E3 ubiquitin ligase RBR family
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arih1-201 (1)    Ensembl 2456
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arih1 No data available
    MARKER RELATIONSHIPS
    arih1 Contained in: [BAC] DKEY-73N10 (1) (order this)
    arih1 Encodes: [EST] fa18d01
    [cDNA] MGC:66364 (1), MGC:192485 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199758 (1) 2383 bp
    Genomic GenBank:BX571681 (1) 184543 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QB49 (1) 529 aa
    Sequence Information (all 20)
    ORTHOLOGY for arih1 ( Chr: 18 )
    CITATIONS (19)