header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-5056
Gene Name: glutamate-cysteine ligase, catalytic subunit
Gene Symbol: gclc    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cb1049 (1), fe36e11, wu:fe36e11 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have several functions, including anion binding activity; glutamate-cysteine ligase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including alpha-amino acid metabolic process; cell redox homeostasis; and glutathione biosynthetic process. Predicted to localize to the glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in cystic fibrosis; hemolytic anemia; and myocardial infarction. Is expressed in several structures, including alar plate midbrain region; gut; intermediate cell mass of mesoderm; midbrain; and sensory system. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).
Genome Resources: Alliance (1),  Gene:326857 (1),  Ensembl(GRCz11):ENSDARG00000013095 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018448Tg Transgenic Insertion Unknown Unknown DNA
la018450Tg Transgenic Insertion Unknown Unknown DNA
sa35401 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gclc HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency 230450
    {Myocardial infarction, susceptibility to} 608446
    DISEASE ASSOCIATED WITH gclc VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell redox homeostasis (more)
    Cellular Component glutamate-cysteine ligase complex (more)
    Molecular Function ADP binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004308 (1)
  • InterPro:IPR014746 (1)
  • Pfam:PF03074 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gclc-201 (1)    Ensembl 3045
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gclc No data available
    MARKER RELATIONSHIPS
    gclc Contained in: [BAC] CH211-71K24 (1) (order this)
    gclc Encodes: [EST] cb1049 (1) (order this), fe36e11, IMAGE:7153748 (1) (order this)
    [cDNA] MGC:55305 (1) (order this), MGC:85625 (1) (order this), MGC:191729 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199277 (1) 3186 bp
    Genomic GenBank:CR376766 (1) 155126 bp
    Select Tool
    Polypeptide UniProtKB:Q6NV35 (1) 631 aa
    Sequence Clusters UniGene:80394 (1)
    Sequence Information (all 24)
    ORTHOLOGY for gclc ( Chr: 13 )
    CITATIONS (74)