ZFIN ID: ZDB-GENE-030131-482
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Gene Name: AKT1 substrate 1 (proline-rich)
Gene Symbol: akt1s1    Nomenclature History

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Previous Name: wu:fb34a04

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Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to be involved in negative regulation of TOR signaling and negative regulation of protein kinase activity. Predicted to localize to the TORC1 complex and cytoplasm. Is expressed in eye. Orthologous to human AKT1S1 (AKT1 substrate 1).
Genome Resources: Alliance (1),  Gene:566559 (1),  Ensembl(GRCz11):ENSDARG00000074667 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Sasore et al., 2014
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa33194 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa40083 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH akt1s1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH akt1s1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of TOR signaling (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR026682 Proline-rich AKT1 substrate 1 protein
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA akt1s1-201 (1)    Ensembl 2379
    Select Tool
    Browsers: NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM akt1s1 No data available
    MARKER RELATIONSHIPS
    akt1s1 Contained in: [BAC] CH211-152F23
    akt1s1 Encodes: [EST] fb34a04, wz11024
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_687419 (1) 2347 bp
    Select Tool
    Genomic GenBank:BX005066 (1) 172909 bp
    Select Tool
    Polypeptide UniProtKB:E7EY34 (1) 354 aa
    Select Tool
    Sequence Information (all 13)
    ORTHOLOGY for akt1s1 ( Chr: 3 )
    CITATIONS (23)