Gene
ndufs1
- ID
- ZDB-GENE-030131-478
- Name
- NADH:ubiquinone oxidoreductase core subunit S1
- Symbol
- ndufs1 Nomenclature History
- Previous Names
-
- wu:fb33h05
- zgc:92209
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and metal ion binding activity. Predicted to be involved in ATP synthesis coupled electron transport. Predicted to localize to membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92209 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nuclear type mitochondrial complex I deficiency 5 | Alliance | Mitochondrial complex I deficiency, nuclear type 5 | 618226 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000283 | NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site |
| Domain | IPR001041 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| Domain | IPR006656 | Molybdopterin oxidoreductase |
| Domain | IPR006963 | Molybdopterin oxidoreductase, 4Fe-4S domain |
| Domain | IPR015405 | NADH-quinone oxidoreductase, chain G, C-terminal |
| Domain | IPR019574 | NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding |
| Family | IPR010228 | NADH:ubiquinone oxidoreductase, subunit G |
| Homologous_superfamily | IPR036010 | 2Fe-2S ferredoxin-like superfamily |
Domain Details Per Protein
| Protein | Length | 2Fe-2S ferredoxin-like superfamily | 2Fe-2S ferredoxin-type iron-sulfur binding domain | Molybdopterin oxidoreductase | Molybdopterin oxidoreductase, 4Fe-4S domain | NADH-quinone oxidoreductase, chain G, C-terminal | NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site | NADH:ubiquinone oxidoreductase, subunit G | NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5RKM2
|
731 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
ndufs1-201
(1)
|
2515 nt |
Interactions and Pathways
No data available
Plasmids
No data available