Gene
ndufs1
- ID
- ZDB-GENE-030131-478
- Name
- NADH:ubiquinone oxidoreductase core subunit S1
- Symbol
- ndufs1 Nomenclature History
- Previous Names
-
- wu:fb33h05
- zgc:92209
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and metal ion binding activity. Predicted to act upstream of or within ATP synthesis coupled electron transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92209 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nuclear type mitochondrial complex I deficiency 5 | Alliance | Mitochondrial complex I deficiency, nuclear type 5 | 618226 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000283 | NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site |
| Domain | IPR001041 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| Domain | IPR006656 | Molybdopterin oxidoreductase |
| Domain | IPR006963 | Molybdopterin oxidoreductase, 4Fe-4S domain |
| Domain | IPR019574 | NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding |
| Family | IPR010228 | NADH:ubiquinone oxidoreductase, subunit G |
| Homologous_superfamily | IPR036010 | 2Fe-2S ferredoxin-like superfamily |
Domain Details Per Protein
| Protein | Length | 2Fe-2S ferredoxin-like superfamily | 2Fe-2S ferredoxin-type iron-sulfur binding domain | Molybdopterin oxidoreductase | Molybdopterin oxidoreductase, 4Fe-4S domain | NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site | NADH:ubiquinone oxidoreductase, subunit G | NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5RKM2
|
731 | |||||||
|
UniProtKB:A0A2R8RNT6
|
766 | |||||||
|
UniProtKB:F1RDA6
|
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
ndufs1-201
(1)
|
2515 nt |
Interactions and Pathways
No data available
Plasmids
No data available