Gene

ndufs1

ID

ZDB-GENE-030131-478

Name

NADH:ubiquinone oxidoreductase core subunit S1

Symbol

ndufs1 Nomenclature History

Previous Names

wu:fb33h05
zgc:92209

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have several functions, including 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and electron transfer activity. Predicted to be involved in ATP synthesis coupled electron transport. Predicted to localize to membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder and mitochondrial complex I deficiency. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1).

Genome Resources

Note

None

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

MGC:92209 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ndufs1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nuclear type mitochondrial complex I deficiency 5	Alliance	Mitochondrial complex I deficiency, nuclear type 5	618226

Associated With ndufs1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000283	NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
Domain	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain
Domain	IPR006656	Molybdopterin oxidoreductase
Domain	IPR006963	Molybdopterin oxidoreductase, 4Fe-4S domain
Domain	IPR015405	NADH-quinone oxidoreductase, chain G, C-terminal
Domain	IPR019574	NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
Family	IPR010228	NADH:ubiquinone oxidoreductase, subunit G
Homologous_superfamily	IPR036010	2Fe-2S ferredoxin-like superfamily