Gene

ndufs1

ID
ZDB-GENE-030131-478
Name
NADH:ubiquinone oxidoreductase core subunit S1
Symbol
ndufs1 Nomenclature History
Previous Names
  • wu:fb33h05
  • zgc:92209
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and metal ion binding activity. Predicted to be involved in ATP synthesis coupled electron transport. Predicted to localize to membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ndufs1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nuclear type mitochondrial complex I deficiency 5 Alliance Mitochondrial complex I deficiency, nuclear type 5 618226
Associated With ndufs1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
Domain IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
Domain IPR006656 Molybdopterin oxidoreductase
Domain IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain
Domain IPR015405 NADH-quinone oxidoreductase, chain G, C-terminal
Domain IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
Family IPR010228 NADH:ubiquinone oxidoreductase, subunit G
Homologous_superfamily IPR036010 2Fe-2S ferredoxin-like superfamily
Domain Details Per Protein
Protein Length 2Fe-2S ferredoxin-like superfamily 2Fe-2S ferredoxin-type iron-sulfur binding domain Molybdopterin oxidoreductase Molybdopterin oxidoreductase, 4Fe-4S domain NADH-quinone oxidoreductase, chain G, C-terminal NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site NADH:ubiquinone oxidoreductase, subunit G NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
UniProtKB:Q5RKM2 731
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations