Gene
ndufs1
- ID
- ZDB-GENE-030131-478
- Name
- NADH:ubiquinone oxidoreductase core subunit S1
- Symbol
- ndufs1 Nomenclature History
- Previous Names
-
- wu:fb33h05
- zgc:92209
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have several functions, including 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and electron transfer activity. Predicted to be involved in ATP synthesis coupled electron transport. Predicted to localize to membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder and mitochondrial complex I deficiency. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1).
- Genome Resources
- Note
- None
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92209 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
nuclear type mitochondrial complex I deficiency 5 | Alliance | Mitochondrial complex I deficiency, nuclear type 5 | 618226 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR000283 | NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site |
Domain | IPR001041 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
Domain | IPR006656 | Molybdopterin oxidoreductase |
Domain | IPR006963 | Molybdopterin oxidoreductase, 4Fe-4S domain |
Domain | IPR015405 | NADH-quinone oxidoreductase, chain G, C-terminal |
Domain | IPR019574 | NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding |
Family | IPR010228 | NADH:ubiquinone oxidoreductase, subunit G |
Homologous_superfamily | IPR036010 | 2Fe-2S ferredoxin-like superfamily |
Domain Details Per Protein
Protein | Length | 2Fe-2S ferredoxin-like superfamily | 2Fe-2S ferredoxin-type iron-sulfur binding domain | Molybdopterin oxidoreductase | Molybdopterin oxidoreductase, 4Fe-4S domain | NADH-quinone oxidoreductase, chain G, C-terminal | NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site | NADH:ubiquinone oxidoreductase, subunit G | NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q5RKM2
|
731 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
ndufs1-201
(1)
|
2515 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl