Gene

tgif1

ID

ZDB-GENE-030131-475

Name

TGFB-induced factor homeobox 1

Symbol

tgif1 Nomenclature History

Previous Names

fa06h05
fb33g11
wu:fa06h05
wu:fb33g11
zgc:55852

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including nervous system development; regulation of signal transduction; and sensory epithelium regeneration. Predicted to localize to nuclear chromatin. Is expressed in several structures, including forebrain neural plate; neural tube; presumptive diencephalon; retinal neural layer; and spinal cord neural keel. Used to study holoprosencephaly. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to human TGIF1 (TGFB induced factor homeobox 1).

Genome Resources

Note

None

Expression

All Expression Data

7 figures from 5 publications

Cross-Species Comparison

High Throughput Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tgif1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
holoprosencephaly 4	Alliance	Holoprosencephaly 4	142946

Associated With tgif1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
holoprosencephaly	WT + MO1-tgif1	standard conditions	Gongal et al., 2008

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001356	Homeobox domain
Domain	IPR008422	Homeobox KN domain
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily

Domain Details Per Protein

Protein	Length	Homeobox domain	Homeobox KN domain	Homeobox-like domain superfamily
UniProtKB:R4GEZ0 InterPro	264
UniProtKB:F8W267 InterPro	192
UniProtKB:Q803F0 InterPro	273

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	tgif1-201 (1) Ensembl	2302 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tgif1-202 (1) Ensembl	730 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tgif1-203 (1) Ensembl	3067 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tgif1	polyclonal	tgif1	IgG	Rabbit	IHC WB	Santa Cruz Biotechnology, Inc.	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Ensembl Gene Tree

Citations