Gene
tgif1
- ID
- ZDB-GENE-030131-475
- Name
- TGFB-induced factor homeobox 1
- Symbol
- tgif1 Nomenclature History
- Previous Names
-
- fa06h05
- fb33g11
- wu:fa06h05
- wu:fb33g11
- zgc:55852
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including nervous system development; regulation of signal transduction; and sensory epithelium regeneration. Predicted to localize to nuclear chromatin. Is expressed in several structures, including forebrain neural plate; neural tube; presumptive diencephalon; retinal neural layer; and spinal cord neural keel. Used to study holoprosencephaly. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to human TGIF1 (TGFB induced factor homeobox 1).
- Genome Resources
- Note
- None
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55852 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
holoprosencephaly 4 | Alliance | Holoprosencephaly 4 | 142946 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
holoprosencephaly | WT + MO1-tgif1 | standard conditions | Gongal et al., 2008 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Homeobox domain | Homeobox KN domain | Homeobox-like domain superfamily |
---|---|---|---|---|
UniProtKB:F8W267
|
192 | |||
UniProtKB:Q803F0
|
273 | |||
UniProtKB:R4GEZ0
|
264 |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-tgif1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
1 |
Plasmids
No data available
- Gene Tree
- Ensembl