ZFIN ID: ZDB-GENE-030131-4637
Gene Name: HEXIM P-TEFb complex subunit 1
Gene Symbol: hexim1    Nomenclature History

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Previous Names: fd44h02, wu:fd44h02, zgc:162976

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have 7SK snRNA binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in protein-containing complex assembly. Predicted to localize to cytoplasm and nucleoplasm. Is expressed in head. Orthologous to several human genes including HEXIM1 (HEXIM P-TEFb complex subunit 1).
Genome Resources: Alliance (1),  Gene:562319 (1),  Ensembl(GRCz11):ENSDARG00000036482 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22060 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35236 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: Fig. 4 from Sun et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH hexim1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hexim1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein-containing complex assembly (more)
    Cellular Component cytoplasm (more)
    Molecular Function cyclin-dependent protein serine/threonine kinase inhibitor activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hexim1-201 (1)    Ensembl 1546
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB1-hexim1 polyclonal IgG Rabbit WB Bethyl Laboratories, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hexim1 No data available
    MARKER RELATIONSHIPS
    hexim1 Contained in: [BAC] DKEY-110P6 (1) (order this)
    hexim1 Encodes: [EST] fd44h02
    [cDNA] MGC:162976 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001098389 (1) 1375 nt
    Genomic GenBank:CT583704 (1) 62316 nt
    Select Tool
    Polypeptide UniProtKB:A5D8S8 (1) 319 aa
    Sequence Information (all 13)
    ORTHOLOGY for hexim1 ( Chr: 12 )
    CITATIONS (27)