Gene

dhx37

ID
ZDB-GENE-030131-4505
Name
DEAH (Asp-Glu-Ala-His) box polypeptide 37
Symbol
dhx37 Nomenclature History
Previous Names
  • fd11d06
  • im:7151586
  • wu:fd11d06
  • zgc:158802
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have RNA binding activity. Involved in positive regulation of mRNA splicing, via spliceosome. Predicted to localize to nucleolus. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dhx37 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
46, XY sex reversal 11 273250
Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies 618731
Associated With dhx37 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
Domain IPR001650 Helicase, C-terminal
Domain IPR003593 AAA+ ATPase domain
Domain IPR007502 Helicase-associated domain
Domain IPR011545 DEAD/DEAH box helicase domain
Domain IPR011709 Domain of unknown function DUF1605
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length AAA+ ATPase domain DEAD/DEAH box helicase domain DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site Domain of unknown function DUF1605 Helicase-associated domain Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase
UniProtKB:B8JLP0 1152
UniProtKB:A2RV37 1152
UniProtKB:A0A0B6VLS4 1152
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations