Gene

guf1

ID
ZDB-GENE-030131-4289
Name
GUF1 homolog, GTPase
Symbol
guf1 Nomenclature History
Previous Names
  • fc88c11
  • im:6906935
  • wu:fc88c11 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have GTP binding activity; GTPase activity; and ribosome binding activity. Predicted to be involved in positive regulation of translation and translation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 40. Orthologous to human GUF1 (GUF1 homolog, GTPase).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With guf1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early infantile epileptic encephalopathy 40 Alliance ?Epileptic encephalopathy, early infantile, 40 617065
Associated With guf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR031157 Tr-type G domain, conserved site
Domain IPR000640 Elongation factor EFG, domain V-like
Domain IPR005225 Small GTP-binding protein domain
Domain IPR013842 GTP-binding protein LepA, C-terminal
Domain IPR035654 Elongation factor 4, domain IV
Family IPR006297 Elongation factor 4
Homologous_superfamily IPR009000 Translation protein, beta-barrel domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR035647 EF-G domain III/V-like
Homologous_superfamily IPR038363 LepA, C-terminal domain superfamily
Domain Details Per Protein
Protein Length EF-G domain III/V-like Elongation factor 4 Elongation factor 4, domain IV Elongation factor EFG, domain V-like GTP-binding protein LepA, C-terminal LepA, C-terminal domain superfamily P-loop containing nucleoside triphosphate hydrolase Small GTP-binding protein domain Translation protein, beta-barrel domain superfamily Tr-type G domain, conserved site
UniProtKB:E7FFK6 672
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations