ZFIN ID: ZDB-GENE-030131-4218
Gene Name: protocadherin 19
Gene Symbol: pcdh19    Nomenclature History

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Previous Names: fc83e05, wu:fc83e05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits calcium ion binding activity and identical protein binding activity. Involved in brain morphogenesis; neural tube formation; and visual perception. Localizes to integral component of membrane. Is expressed in several structures, including brain; eye; immature eye; posterior neural keel; and spinal cord. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 9. Orthologous to human PCDH19 (protocadherin 19).
Genome Resources: Alliance (1),  Gene:555688 (1),  Ensembl(GRCz11):ENSDARG00000034344 (2)
GENE EXPRESSION
All Expression Data: 24 figures from 6 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011465Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012600Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • os50 Small Deletion Unknown Unknown TALEN
    os51 Small Deletion Unknown Unknown TALEN
    os52 Small Deletion Unknown Unknown TALEN
    sa952 Point Mutation Unknown Premature Stop ENU
    sa12445 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22530 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22531 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30984 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35742 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35743 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pcdh19 N/A 2
    MO2-pcdh19 N/A 3
    MO3-pcdh19 N/A 1
    TALEN1-pcdh19 1
    DISEASE ASSOCIATED WITH pcdh19 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 9 Alliance Epileptic encephalopathy, early infantile, 9 300088
    DISEASE ASSOCIATED WITH pcdh19 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain morphogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pcdh19-201 (1)    Ensembl 6346
    pcdh19-202 (1)    Ensembl 3054
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-pcdh19 polyclonal Rabbit WB 1
    CONSTRUCTS WITH SEQUENCES FROM pcdh19
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(pcdh19:GAL4-VP16-FRT,5xUAS:LIFEACT-GFP) pcdh19UAS FRTGAL4GFPLIFEACTVP16 Danio rerio 1 2
    MARKER RELATIONSHIPS
    pcdh19 Contained in: [BAC] CH211-237H22 (1)
    [Fosmid] CH1073-359P3 (1)
    pcdh19 Encodes: [EST] fc83e05
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001127519 (1) 6322 nt
    Genomic GenBank:CU151882 (1) 128581 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QME5 (1) 1094 aa
    Sequence Information (all 35)
    ORTHOLOGY for pcdh19 ( Chr: 14 )
    CITATIONS (33)