ZFIN ID: ZDB-GENE-030131-4145
Gene Name: MAP/microtubule affinity-regulating kinase 2a
Gene Symbol: mark2a    Nomenclature History

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Previous Names: fc75f05, si:dkey-175m17.8, wu:fc75f05 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to localize to the cytoplasm. Orthologous to human MARK2 (microtubule affinity regulating kinase 2).
Genome Resources: Alliance (1),  Gene:562231 (1),  Ensembl(GRCz11):ENSDARG00000079905 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1844 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23953 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mark2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mark2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Domain IPR001772 Kinase associated domain 1 (KA1)
    Domain IPR015940 Ubiquitin-associated domain
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Homologous_superfamily IPR028375 KA1 domain/Ssp2, C-terminal
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript mark2a-207 (1)    Ensembl 854
    mRNA mark2a-203 (1)    Ensembl 455
    mark2a-204 (1)    Ensembl 726
    mark2a-205 (1)    Ensembl 3084
    mark2a-206 (1)    Ensembl 419
    ncRNA mark2a-006 (1)    Ensembl 841
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mark2a No data available
    MARKER RELATIONSHIPS
    mark2a Contained in: [BAC] DKEY-175M17 (1) (order this)
    mark2a Encodes: [EST] fc75f05
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005161367 (1) 4526 nt
    Genomic GenBank:BX530031 (1) 160736 nt
    Select Tool
    Polypeptide UniProtKB:E7FBX4 (1) 759 aa
    Sequence Information (all 61)
    ORTHOLOGY for mark2a ( Chr: 21 )
    CITATIONS (23)