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ZIRC
ZFIN ID: ZDB-GENE-030131-4027
Gene Name: F-box protein 5
Gene Symbol: fbxo5    Nomenclature History

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Previous Names: emi1 (1), fc65h02, harpy (1), hrp (1), rca1 (1), wu:fc65h02, wu:fe06e07, wu:fz79f03, zgc:136397, zgc:158541

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have ubiquitin ligase inhibitor activity. Involved in several processes, including hemopoiesis; mitotic cytokinesis; and negative regulation of mitotic nuclear division. Predicted to localize to the cytoplasm; nucleus; and spindle. Is expressed in several structures, including alar plate midbrain region; blood; nervous system; optic vesicle; and segmental plate. Orthologous to human FBXO5 (F-box protein 5).
Genome Resources: Alliance (1),  Gene:445392 (1),  Ensembl(GRCz11):ENSDARG00000039020 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 4 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2004 [IMAGE:7158631]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2648Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012426Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018683Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8720 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18636 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31965 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38972 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42299 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ti245 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tiy121 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • x1 Complex Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fbxo5 N/A 2
    MO2-fbxo5 N/A 1
    MO3-fbxo5 N/A 1
    MO4-fbxo5 N/A 1
    MO5-fbxo5 N/A 2
    DISEASE ASSOCIATED WITH fbxo5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fbxo5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell division (more)
    Cellular Component cytoplasm (more)
    Molecular Function ubiquitin ligase inhibitor activity (more)
    GO Terms (all 18)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript fbxo5-202 (1)    Ensembl 831
    mRNA fbxo5-201 (1)    Ensembl 1716
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-fbxo5 polyclonal Rabbit Life Technologies (Invitrogen)
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fbxo5 No data available
    MARKER RELATIONSHIPS
    fbxo5 Contained in: [BAC] CH73-211G16 (1) (order this), DKEYP-9B4 (1)
    fbxo5 Contains: [SNP] rs3728595 (1), rs3728596 (1), rs3728597 (1), rs3728598 (1)
    fbxo5 Encodes: [EST] fc65h02, fe06e07 (1), fz79f03, IMAGE:7158631 (1) (order this)
    [cDNA] MGC:136397 (1) (order this), MGC:152677 (1) (order this), MGC:158541 (1) (order this), MGC:162839 (1) (order this), MGC:191657 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003869 (1) 1681 bp
    Genomic GenBank:CR847786 (1) 156551 bp
    Select Tool
    Polypeptide UniProtKB:A3KP15 (1) 384 aa
    Sequence Clusters UniGene:79262 (1)
    Sequence Information (all 44)
    ORTHOLOGY for fbxo5 ( Chr: 13 )
    CITATIONS (49)