Gene

inppl1a

ID
ZDB-GENE-030131-3904
Name
inositol polyphosphate phosphatase-like 1a
Symbol
inppl1a Nomenclature History
Previous Names
  • ship2a (1)
  • fc58a04
  • wu:fc58a04 (1)
  • zgc:198309
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have actin binding activity and hydrolase activity. Involved in BMP signaling pathway; negative regulation of fibroblast growth factor receptor signaling pathway; and negative regulation of neutrophil chemotaxis. Predicted to localize to nuclear speck. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Is expressed in blastoderm and blastodisc. Orthologous to human INPPL1 (inositol polyphosphate phosphatase like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Jurynec et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With inppl1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Opsismodysplasia 258480
Associated With inppl1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000300 Inositol polyphosphate-related phosphatase
Domain IPR000980 SH2 domain
Domain IPR001660 Sterile alpha motif domain
Domain IPR005135 Endonuclease/exonuclease/phosphatase
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR036691 Endonuclease/exonuclease/phosphatase superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Endonuclease/exonuclease/phosphatase Endonuclease/exonuclease/phosphatase superfamily Inositol polyphosphate-related phosphatase SH2 domain SH2 domain superfamily Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily
UniProtKB:Q2I6J1 1266
UniProtKB:A0A0J9YJ69 260
UniProtKB:A0A0R4IB77 1003
UniProtKB:A0A0R4ISQ5 785
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations