ZFIN ID: ZDB-GENE-030131-3904
Gene Name: inositol polyphosphate phosphatase-like 1a
Gene Symbol: inppl1a    Nomenclature History

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Previous Names: ship2a (1), fc58a04, wu:fc58a04 (1), zgc:198309

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have actin binding activity and hydrolase activity. Involved in BMP signaling pathway; negative regulation of fibroblast growth factor receptor signaling pathway; and negative regulation of neutrophil chemotaxis. Predicted to localize to the nuclear speck. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Is expressed in blastoderm and blastodisc. Orthologous to human INPPL1 (inositol polyphosphate phosphatase like 1).
Genome Resources: Alliance (1),  Gene:325179 (1),  Ensembl(GRCz11):ENSDARG00000104222 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Gastrula:50%-epiboly (5.25h-5.66h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32068 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-inppl1a N/A 1
    MO2-inppl1a N/A 1
    MO3-inppl1a N/A 1
    MO4-inppl1a N/A 1
    DISEASE ASSOCIATED WITH inppl1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Opsismodysplasia 258480
    DISEASE ASSOCIATED WITH inppl1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of neutrophil chemotaxis (more)
    Cellular Component nuclear speck (more)
    Molecular Function actin binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000300 Inositol polyphosphate-related phosphatase
    Domain IPR000980 SH2 domain
    Domain IPR001660 Sterile alpha motif domain
    Domain IPR005135 Endonuclease/exonuclease/phosphatase
    Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
    Homologous_superfamily IPR036691 Endonuclease/exonuclease/phosphatase superfamily
    Homologous_superfamily IPR036860 SH2 domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA inppl1a-201 (1)    Ensembl 4238
    inppl1a-203 (1)    Ensembl 781
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM inppl1a No data available
    MARKER RELATIONSHIPS
    inppl1a Contained in: [Fosmid] ZFOS-1813G3 (1)
    inppl1a Encodes: [EST] fc58a04
    [cDNA] MGC:198309 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001039804 (1) 3978 bp
    Genomic GenBank:FP929031 (1) 40932 bp
    Select Tool
    Polypeptide UniProtKB:Q2I6J1 (1) 1266 aa
    Sequence Information (all 21)
    ORTHOLOGY for inppl1a ( Chr: 15 )
    CITATIONS (23)