ZFIN ID: ZDB-GENE-030131-3844 |
Gene Name: | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | ||||||
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Gene Symbol: | uchl1 Nomenclature History | ||||||
Previous Names: | cb358 (1), wu:fc55h08 | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Chr: 1 Mapping Details/Browsers | ||||||
Description: | Predicted to have thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in protein deubiquitination. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary spastic paraplegia; and late onset Parkinson's disease. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1). | ||||||
Genome Resources: | Alliance (1), Gene:325119 (1), Ensembl(GRCz11):ENSDARG00000026871 (2) |
All Expression Data: | 10 figures from 5 publications |
Directly Submitted Expression Data: | 5 figures (39 images) from Thisse et al., 2001 [cb358] |
Wild-type Stages, Structures: | Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult) |
Curated Microarray Expression: | GEO (1) |
Allele | Type | Localization | Consequence | Mutagen | Suppliers |
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sa38261 | Point Mutation | Unknown | Premature Stop | ENU |
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zko428a | Small Deletion | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Publications |
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CRISPR1-uchl1 | 1 | |
MO1-uchl1 | N/A | 1 |
Ontology | GO Term |
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Biological Process | protein deubiquitination (more) |
Cellular Component | cytoplasm (more) |
Molecular Function | cysteine-type peptidase activity (more) |
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Type | Name | Length (nt) | Analysis | |
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mRNA |
uchl1-201
(1)
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1490 |
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ncRNA |
uchl1-002
(1)
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338 |
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Browsers: UCSC, NCBI, Ensembl, ZFIN |
uchl1 Contained in: |
[BAC]
CH211-240P12 (1) (order this)
[Fosmid] ZFOS-2069A7 (1) |
uchl1 Encodes: |
[EST]
cb358 (1),
fc55h08
[cDNA] MGC:56535 (1) (order this) |
Type | Accession # | Length (bp/aa) | Analysis |
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RNA | RefSeq:NM_201477 (1) | 1118 bp |
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Genomic | GenBank:CR376846 (1) | 145408 bp | |
Polypeptide | UniProtKB:Q6YI49 (1) | 218 aa |
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Sequence Clusters | UniGene:8724 (1) |