ZFIN ID: ZDB-GENE-030131-341
Gene Name: high mobility group box 1a
Gene Symbol: hmgb1a    Nomenclature History

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Previous Names: hmgb1, ik:tdsubc_1a5, tdsubc_1a5, wu:fb23c02, xx:tdsubc_1a5, zgc:77104 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have DNA binding activity, bending and transcription factor binding activity. Involved in axon regeneration; forebrain development; and response to cold. Localizes to plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and congestive heart failure. Is expressed in several structures, including blastomere; epidermis; intermediate cell mass of mesoderm; nervous system; and ventral mesoderm. Orthologous to human HMGB1 (high mobility group box 1).
Genome Resources: Alliance (1),  Gene:321622 (1),  Ensembl(GRCz11):ENSDARG00000099175 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027179Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hmgb1a N/A 3
    MO2-hmgb1a N/A 1
    MO3-hmgb1a N/A 1
    MO4-hmgb1a N/A 1
    MO5-hmgb1a N/A 1
    DISEASE ASSOCIATED WITH hmgb1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hmgb1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to cold (more)
    Cellular Component plasma membrane (more)
    Molecular Function DNA binding (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-hmgb1a Rabbit IHC, WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hmgb1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(actb2:LOXP-hmgb1a-ECFP-LOXP-zgc:114046-mCherry) actb2 ECFPhmgb1aLOXPmCherryzgc:114046 Danio rerio 1 1
    Tg(actb2:LOXP-STOP-LOXP-hmgb1-mCherry) actb2 hmgb1amCherry Danio rerio 1 13
    Tg(EPV.Tp1-Ocu.Hbb2:hmgb1-mCherry) hmgb1amCherry Danio rerioOryctolagus cuniclus 2 41
    Tg(ins:hmgb1-EGFP) ins EGFPhmgb1a Danio rerio 1 6
    MARKER RELATIONSHIPS
    hmgb1a Contained in: [BAC] CH211-167B13
    hmgb1a Encodes: [EST] fb23c02, fc36f10 (1) (order this), tdsubc_1a5
    [cDNA] MGC:56110 (1), MGC:77104 (1), MGC:192395 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199555 (1) 1422 nt
    Genomic GenBank:CR753900 113731 nt
    Select Tool
    Polypeptide UniProtKB:Q6NX86 (1) 205 aa
    Sequence Information (all 26)
    ORTHOLOGY for hmgb1a ( Chr: 10 )
    CITATIONS (84)