ZFIN ID: ZDB-GENE-030131-3404
Gene Name: TSC complex subunit 1b
Gene Symbol: tsc1b    Nomenclature History

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Previous Names: fc38b04, wu:fc38b04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to be involved in negative regulation of TOR signaling; negative regulation of insulin receptor signaling pathway; and regulation of cell cycle. Predicted to localize to TSC1-TSC2 complex. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1).
Genome Resources: Alliance (1),  Gene:100330617 (1),  Ensembl(GRCz11):ENSDARG00000057918 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021837Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa916 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37267 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43613 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tsc1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lymphangioleiomyomatosis Alliance Lymphangioleiomyomatosis 606690
    tuberous sclerosis 1 Alliance Tuberous sclerosis-1 191100
    Focal cortical dysplasia, type II, somatic 607341
    DISEASE ASSOCIATED WITH tsc1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of insulin receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tsc1b-201 (1)    Ensembl 5515
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tsc1b No data available
    MARKER RELATIONSHIPS
    tsc1b Contained in: [BAC] CH211-196O18 (1)
    tsc1b Encodes: [EST] fc38b04
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001282392 (1)
    Genomic GenBank:BX088716 (1) 156079 nt
    Select Tool
    Polypeptide UniProtKB:E7FEJ0 (1) 1228 aa
    Sequence Information (all 7)
    ORTHOLOGY for tsc1b ( Chr: 21 )
    CITATIONS (24)