ZFIN ID: ZDB-GENE-030131-3404
Gene Name: TSC complex subunit 1b
Gene Symbol: tsc1b
Sequence Ontology ID : SO:0000704

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Previous Names: fc38b04, wu:fc38b04

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to be involved in negative regulation of TOR signaling, negative regulation of insulin receptor signaling pathway, and regulation of cell cycle; predicted to localize to the TSC1-TSC2  ...
GENE EXPRESSION
All Expression Data: Fig. 4 from Lee et al., 2018
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021837Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa916 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37267 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43613 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tsc1b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    lymphangioleiomyomatosis Lymphangioleiomyomatosis 606690
    tuberous sclerosis 1 Tuberous sclerosis-1 191100
    Focal cortical dysplasia, type II, somatic 607341
    Focal cortical dysplasia, type II, somatic 607341
    DISEASE ASSOCIATED WITH tsc1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of insulin receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR007483 (1)
  • Pfam:PF04388 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tsc1b-001 (1) 5515
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tsc1b No data available
    MARKER RELATIONSHIPS
    tsc1bContained in: [BAC] CH211-196O18 (1) (order this)
    tsc1bEncodes: [EST] fc38b04
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001282392 (1)
    Genomic GenBank:BX088716 (1) 156079bp
    Select Tool
    Polypeptide UniProtKB:E7FEJ0 (1) 1228aa
    Sequence Information (all 7)
    OTHER tsc1b GENE PAGES
  • Alliance (1)
  • Gene:100330617 (1)
  • VEGA:OTTDARG00000023532 (1)
  • Ensembl(GRCz11):ENSDARG00000057918 (2)
  • ORTHOLOGY for tsc1b (Chr: 21)
    CITATIONS (21)