Gene

cul3a

ID
ZDB-GENE-030131-3376
Name
cullin 3a
Symbol
cul3a Nomenclature History
Previous Names
  • cul3
  • wu:fc37e01
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have ubiquitin protein ligase binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to localize to cullin-RING ubiquitin ligase complex. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Edwards et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cul3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with or without autism or seizures 619239
Pseudohypoaldosteronism, type IIE 614496
Associated With cul3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR016157 Cullin, conserved site
Domain IPR001373 Cullin, N-terminal
Domain IPR016158 Cullin homology domain
Domain IPR019559 Cullin protein, neddylation domain
Homologous_superfamily IPR016159 Cullin repeat-like-containing domain superfamily
Homologous_superfamily IPR036317 Cullin homology domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Cullin, conserved site Cullin homology domain Cullin homology domain superfamily Cullin, N-terminal Cullin protein, neddylation domain Cullin repeat-like-containing domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:F6NVK8
UniProtKB:Q6TEL5 766
UniProtKB:Q6P0Z1 766
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations