Gene

dhodh

ID
ZDB-GENE-030131-3157
Name
dihydroorotate dehydrogenase
Symbol
dhodh Nomenclature History
Previous Names
  • wu:fc29a01
  • zgc:103492
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have dihydroorotate dehydrogenase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleotide biosynthetic process. Predicted to localize to mitochondrial inner membrane. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dhodh Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
postaxial acrofacial dysostosis Alliance Miller syndrome 263750
Associated With dhodh Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001295 Dihydroorotate dehydrogenase, conserved site
Domain IPR005720 Dihydroorotate dehydrogenase domain
Family IPR005719 Dihydroorotate dehydrogenase, class 2
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
Domain Details Per Protein
Protein Length Aldolase-type TIM barrel Dihydroorotate dehydrogenase, class 2 Dihydroorotate dehydrogenase, conserved site Dihydroorotate dehydrogenase domain
UniProtKB:Q5PR57 407
UniProtKB:F1QNH4 407
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations