ZFIN ID: ZDB-GENE-030131-3157
Gene Name: dihydroorotate dehydrogenase
Gene Symbol: dhodh    Nomenclature History

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Previous Names: wu:fc29a01, zgc:103492

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have dihydroorotate dehydrogenase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleotide biosynthetic process. Predicted to localize to mitochondrial inner membrane. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)).
Genome Resources: Alliance (1),  Gene:494065 (1),  Ensembl(GRCz11):ENSDARG00000051889 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:103492]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41042 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dhodh HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    postaxial acrofacial dysostosis Alliance Miller syndrome 263750
    DISEASE ASSOCIATED WITH dhodh VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process 'de novo' pyrimidine nucleobase biosynthetic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dhodh-201 (1)    Ensembl 1562
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dhodh No data available
    MARKER RELATIONSHIPS
    dhodh Contained in: [BAC] DKEY-90B24 (1) (order this)
    dhodh Encodes: [EST] fc29a01
    [cDNA] MGC:103492 (1), MGC:191441 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001008608 (1) 1584 nt
    Genomic GenBank:CR382281 (1) 143523 nt
    Select Tool
    Polypeptide UniProtKB:F1QNH4 (1) 407 aa
    Sequence Information (all 18)
    ORTHOLOGY for dhodh ( Chr: 7 )
    CITATIONS (25)