ZFIN ID: ZDB-GENE-030131-3043
Gene Name: excision repair cross-complementation group 3
Gene Symbol: ercc3    Nomenclature History

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Previous Names: wu:fc25f08, xpb (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to contribute to DNA-dependent ATPase activity and RNA polymerase II CTD heptapeptide repeat kinase activity. Predicted to be involved in apoptotic process; nucleic acid metabolic process; and response to UV. Predicted to localize to nucleotide-excision repair factor 3 complex; transcription factor TFIIH holo complex; and transcription preinitiation complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit).
Genome Resources: Alliance (1),  Gene:324323 (1),  Ensembl(GRCz11):ENSDARG00000002402 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55607]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029271Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ercc3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    photosensitive trichothiodystrophy 2 Alliance Trichothiodystrophy 2, photosensitive 616390
    xeroderma pigmentosum group B Alliance Xeroderma pigmentosum, group B 610651
    DISEASE ASSOCIATED WITH ercc3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process apoptotic process (more)
    Cellular Component transcription factor TFIIH holo complex (more)
    Molecular Function 3'-5' DNA helicase activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ercc3-201 (1)    Ensembl 2759
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ercc3 No data available
    MARKER RELATIONSHIPS
    ercc3 Contained in: [BAC] DKEY-32H20 (1) (order this)
    ercc3 Contains: [SNP] rs3727951 (1), rs3727952 (1), rs3727953 (1)
    ercc3 Encodes: [EST] fc25f08
    [cDNA] MGC:55607 (1), MGC:192753 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201582 (1) 2780 nt
    Genomic GenBank:BX927387 (1) 175517 nt
    Select Tool
    Polypeptide UniProtKB:B2GSW0 (1) 782 aa
    Sequence Information (all 17)
    ORTHOLOGY for ercc3 ( Chr: 6 )
    CITATIONS (29)