ZFIN ID: ZDB-GENE-030131-2976
Gene Name: origin recognition complex, subunit 6
Gene Symbol: orc6    Nomenclature History

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Previous Names: orc6l, wu:fa94a09, wu:fc22h10, zgc:65798, zgc:77185

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have DNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to localize to nuclear origin of replication recognition complex. Is expressed in central nervous system; eye; intermediate cell mass of mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6).
Genome Resources: Alliance (1),  Gene:324256 (1),  Ensembl(GRCz11):ENSDARG00000075682 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:65798]
  6 figures (10 images) from Thisse et al., 2004 [IMAGE:6907825]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40983 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-orc6 N/A 1
    DISEASE ASSOCIATED WITH orc6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Meier-Gorlin syndrome 3 Alliance Meier-Gorlin syndrome 3 613803
    DISEASE ASSOCIATED WITH orc6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA replication (more)
    Cellular Component nuclear origin of replication recognition complex (more)
    Molecular Function DNA binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA orc6-201 (1)    Ensembl 1692
    orc6-202 (1)    Ensembl 2054
    orc6-203 (1)    Ensembl 885
    orc6-204 (1)    Ensembl 904
    ncRNA orc6-002 (1)    Ensembl 731
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM orc6 No data available
    MARKER RELATIONSHIPS
    orc6 Contained in: [BAC] RP71-34G2
    orc6 Encodes: [EST] fa94a09 (1), fc22h10, IMAGE:6907825 (1)
    [cDNA] MGC:65798 (1), MGC:77185 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212671 (1) 1398 nt
    Genomic GenBank:AL928906 (1) 161527 nt
    Select Tool
    Polypeptide UniProtKB:Q6ZM36 (1) 256 aa
    Sequence Information (all 18)
    ORTHOLOGY for orc6 ( Chr: 7 )
    CITATIONS (24)