Gene

iqgap2

ID
ZDB-GENE-030131-2878
Name
IQ motif containing GTPase activating protein 2
Symbol
iqgap2 Nomenclature History
Previous Names
  • fc20f09
  • si:ch211-157p10.1
  • wu:fc20f09
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have several functions, including GTPase activator activity; Rac GTPase binding activity; and calmodulin binding activity. Involved in glomerular filtration and glomerular visceral epithelial cell development. Predicted to localize to cytoplasm. Is expressed in several structures, including cranial vasculature; gut; pericardial region; pronephros; and sensory system. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Sugano et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With iqgap2 Human Ortholog
No data available
Associated With iqgap2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR000593 RasGAP protein, C-terminal
Domain IPR001202 WW domain
Domain IPR001715 Calponin homology domain
Domain IPR001936 Ras GTPase-activating domain
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036872 CH domain superfamily
Domain Details Per Protein
Protein Length Calponin homology domain CH domain superfamily IQ motif, EF-hand binding site P-loop containing nucleoside triphosphate hydrolase RasGAP protein, C-terminal Ras GTPase-activating domain Rho GTPase activation protein WW domain
UniProtKB:F1QAC1 1673
UniProtKB:A2CE93 1680
UniProtKB:A0A0F6Y5M7 1673
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-iqgap2 polyclonal Rabbit
EUROGENTEC S.A.
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations