ZFIN ID: ZDB-GENE-030131-2317
Gene Name: EWS RNA-binding protein 1a
Gene Symbol: ewsr1a    Nomenclature History

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Previous Names: fc04c01, wu:fc04c01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits chromatin binding activity. Involved in several processes, including central nervous system neuron development; mitotic spindle midzone assembly; and regulation of chondrocyte hypertrophy. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1).
Genome Resources: Alliance (1),  Gene:323597 (1),  Ensembl(GRCz11):ENSDARG00000020258 (1)
GENE EXPRESSION
All Expression Data: Fig. 2 from Azuma et al., 2007
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la017627Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la017628Tg Transgenic Insertion Unknown Unknown DNA
    sa15021 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44719 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zm00260171Tg Transgenic Insertion Unknown Premature Stop DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ewsr1a N/A 1
    DISEASE ASSOCIATED WITH ewsr1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Ewing sarcoma Alliance Ewing sarcoma 612219
    Neuroepithelioma 612219
    DISEASE ASSOCIATED WITH ewsr1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system neuron development (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ewsr1a-201 (1)    Ensembl 2456
    ewsr1a-203 (1)    Ensembl 986
    ncRNA ewsr1a-003 (1)    Ensembl 497
    ewsr1a-004 (1)    Ensembl 1251
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ewsr1a polyclonal Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ewsr1a No data available
    MARKER RELATIONSHIPS
    ewsr1a Contained in: [BAC] CH211-199I18 (1)
    ewsr1a Encodes: [EST] fc04c01
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001115138 (1) 2777 nt
    Genomic GenBank:BX294661 (1) 197237 nt
    Select Tool
    Polypeptide UniProtKB:A0A0B4J1A5 (1) 626 aa
    Sequence Information (all 27)
    ORTHOLOGY for ewsr1a ( Chr: 10 )
    CITATIONS (28)