Gene

ewsr1a

ID

ZDB-GENE-030131-2317

Name

EWS RNA-binding protein 1a

Symbol

ewsr1a Nomenclature History

Previous Names

fc04c01
wu:fc04c01

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Exhibits chromatin binding activity. Involved in several processes, including central nervous system neuron development; mitotic spindle midzone assembly; and regulation of chondrocyte hypertrophy. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ewsr1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Ewing sarcoma	Alliance	Ewing sarcoma	612219
Ewing sarcoma	Alliance	Neuroepithelioma	612219

Associated With ewsr1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR001876	Zinc finger, RanBP2-type
Domain	IPR034869	EWS, RNA recognition motif
Family	IPR034870	TAF15/EWS/TLS family
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily
Homologous_superfamily	IPR036443	Zinc finger, RanBP2-type superfamily

Domain Details Per Protein

Protein	Length	EWS, RNA recognition motif	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA recognition motif domain	TAF15/EWS/TLS family	Zinc finger, RanBP2-type	Zinc finger, RanBP2-type superfamily
UniProtKB:Q6NUX1 InterPro	624
UniProtKB:A0A0B4J1A5 InterPro	626
UniProtKB:A0A8M9QKJ4 InterPro	319
UniProtKB:A0A8M9QBU8 InterPro	597

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ewsr1a-201 (1) Ensembl	Havana	2456 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ewsr1a-203 (1) Ensembl	Havana	986 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ewsr1a-003 (1) Ensembl	Havana	497 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ewsr1a-004 (1) Ensembl	Havana	1251 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ewsr1a	polyclonal	ewsr1a		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations