Gene

cltca

ID
ZDB-GENE-030131-2299
Name
clathrin, heavy chain a (Hc)
Symbol
cltca Nomenclature History
Previous Names
  • cltc (1)
  • cb1033 (1)
  • wu:fc03e11 (1)
  • wu:fc49a11
  • wu:fd07f02
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly; mitotic cell cycle; and receptor-mediated endocytosis. Predicted to localize to clathrin complex; clathrin-coated endocytic vesicle; and spindle. Is expressed in axial vasculature; blood; intermediate cell mass of mesoderm; notochord; and ventral mesoderm. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Orthologous to human CLTC (clathrin heavy chain).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from Thisse et al., 2001
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cltca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant mental retardation 56 Alliance Mental retardation, autosomal dominant 56 617854
Associated With cltca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR015348 Clathrin, heavy chain, linker, core motif
Family IPR016341 Clathrin, heavy chain
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR016025 Clathrin heavy chain, N-terminal
Repeat IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
Repeat IPR022365 Clathrin, heavy chain, propeller repeat
Domain Details Per Protein
Protein Length Armadillo-type fold Clathrin, heavy chain Clathrin, heavy chain, linker, core motif Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat Clathrin, heavy chain/VPS, 7-fold repeat Tetratricopeptide-like helical domain superfamily
UniProtKB:A0A286YAZ4 1684
UniProtKB:F1R966 1680
UniProtKB:Q6DRI2 1680
UniProtKB:E9QD79 1661
UniProtKB:A0A2R8PXZ0 1666
UniProtKB:B3DK43 1680
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations