ZFIN ID: ZDB-GENE-030131-2299
Gene Name: clathrin, heavy chain a (Hc)
Gene Symbol: cltca    Nomenclature History

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Previous Names: cltc (1), cb1033 (1), wu:fc03e11 (1), wu:fc49a11, wu:fd07f02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly; mitotic cell cycle; and receptor-mediated endocytosis. Predicted to localize to clathrin complex; clathrin-coated endocytic vesicle; and spindle. Is expressed in axial vasculature; blood; intermediate cell mass of mesoderm; notochord; and ventral mesoderm. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Orthologous to human CLTC (clathrin heavy chain).
Genome Resources: Alliance (1),  Gene:323579 (1),  Ensembl(GRCz11):ENSDARG00000043493 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 5 figures (7 images) from Thisse et al., 2001 [cb1033]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
DISEASE ASSOCIATED WITH cltca HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant mental retardation 56 Alliance Mental retardation, autosomal dominant 56 617854
DISEASE ASSOCIATED WITH cltca VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process intracellular protein transport (more)
Cellular Component clathrin-coated pit (more)
Molecular Function clathrin light chain binding (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cltca-201 (1)    Ensembl 6443
ncRNA cltca-002 (1)    Ensembl 747
cltca-003 (1)    Ensembl 589
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cltca No data available
MARKER RELATIONSHIPS
cltca Contained in: [BAC] CH211-222E20 (1)
cltca Encodes: [EST] cb1033 (1) (order this), fc03e11, fc49a11 (1), fd07f02
[cDNA] MGC:194792 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001005391 (1) 5372 nt
Genomic GenBank:CR392341 (1) 208667 nt Blast at MegaBLAST
Polypeptide UniProtKB:A0A286YAZ4 (1) 1684 aa
Sequence Information (all 30)
ORTHOLOGY for cltca ( Chr: 10 )
CITATIONS (35)