ZFIN ID: ZDB-GENE-030131-1988
Gene Name: fibronectin leucine rich transmembrane 3
Gene Symbol: flrt3    Nomenclature History

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Previous Names: fb93g11, si:dkeyp-24h12.1, wu:fb75d02, wu:fb93g11 (1), wu:fc10a05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have fibroblast growth factor receptor binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway and positive regulation of synapse assembly. Predicted to localize to extracellular space. Is expressed in several structures, including mesoderm; midbrain hindbrain boundary neural keel; nervous system; optic primordium; and optic vesicle. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3).
Genome Resources: Alliance (1),  Gene:558864 (1),  Ensembl(GRCz11):ENSDARG00000076895 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3691 Point Mutation Unknown Unknown ENU
sa219 Point Mutation Unknown Premature Stop ENU
sa251 Point Mutation Unknown Premature Stop ENU
sa2686 Point Mutation Unknown Premature Stop ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH flrt3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypogonadotropic hypogonadism 21 with or without anosmia Alliance Hypogonadotropic hypogonadism 21 with anosmia 615271
DISEASE ASSOCIATED WITH flrt3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component integral component of membrane (more)
Molecular Function protein binding (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA flrt3-201 (1)    Ensembl 4225
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-flrt3 monoclonal IgG1 , k Mouse IHC 1
CONSTRUCTS WITH SEQUENCES FROM flrt3 No data available
MARKER RELATIONSHIPS
flrt3 Contained in: [BAC] DKEYP-24H12 (1)
flrt3 Encodes: [EST] eu497 (1), fb75d02, fb93g11, fc10a05
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001256646 (1)
Genomic GenBank:BX465200 (1) 65108 nt
Select Tool
Polypeptide UniProtKB:B8A507 (1) 649 aa
Sequence Information (all 23)
ORTHOLOGY for flrt3 ( Chr: 13 )
CITATIONS (29)