Gene
smurf2
- ID
- ZDB-GENE-030131-1830
- Name
- SMAD specific E3 ubiquitin protein ligase 2
- Symbol
- smurf2 Nomenclature History
- Previous Names
-
- wu:fb82a11
- wu:fc41c02
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of BMP signaling pathway; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to localize to cytoplasm. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein ligase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Arslan-Ergul et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR000569 | HECT domain |
| Domain | IPR001202 | WW domain |
| Family | IPR024928 | E3 ubiquitin-protein ligase, SMURF1 type |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | E3 ubiquitin-protein ligase, SMURF1 type | HECT domain | HECT, E3 ligase catalytic domain | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BIZ2
|
764 | |||||||
|
UniProtKB:A9JRZ0
|
765 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
smurf2-201
(1)
|
Havana | 3399 nt |
Interactions and Pathways
No data available
Plasmids
No data available