ZFIN ID: ZDB-GENE-030131-1390
Gene Name: aconitase 2, mitochondrial
Gene Symbol: aco2    Nomenclature History

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Previous Names: cb1017 (1), wu:fa10e03 (1), wu:fb69g04 (1), wu:fc20c11 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to localize to cytosol and mitochondrion. Is expressed in several structures, including adaxial cell; heart tube; musculature system; nervous system; and pronephric duct. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2).
Genome Resources: Alliance (1),  Gene:322670 (1),  Ensembl(GRCz11):ENSDARG00000007294 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22076 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24909 Point Mutation Unknown Splice Site ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH aco2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    infantile cerebellar-retinal degeneration Alliance Infantile cerebellar-retinal degeneration 614559
    optic atrophy 9 Alliance ?Optic atrophy 9 616289
    DISEASE ASSOCIATED WITH aco2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process tricarboxylic acid cycle (more)
    Cellular Component mitochondrion (more)
    Molecular Function 4 iron, 4 sulfur cluster binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aco2-201 (1)    Ensembl 3495
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aco2 No data available
    MARKER RELATIONSHIPS
    aco2 Contained in: [BAC] CH73-139E5 (1), CH211-141O9 (1)
    aco2 Encodes: [EST] cb1017 (1) (order this), fa10e03, fb69g04, fc20c11
    [cDNA] MGC:66073 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_198908 (1) 3491 nt
    Genomic GenBank:BX000473 (1) 180366 nt
    Select Tool
    Polypeptide UniProtKB:F8W4M7 (1) 790 aa
    Sequence Information (all 17)
    ORTHOLOGY for aco2 ( Chr: 12 )
    CITATIONS (29)