ZFIN ID: ZDB-GENE-030131-1291
Gene Name: ribosomal protein L3
Gene Symbol: rpl3    Nomenclature History

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Previous Names: wu:fa99g02, wu:fb65e09, zgc:110350

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have RNA binding activity. Involved in exocrine pancreas development. Predicted to localize to cytosolic large ribosomal subunit. Is expressed in eye; liver; and pancreas. Used to study Shwachman-Diamond syndrome. Orthologous to human RPL3 (ribosomal protein L3).
Genome Resources: Alliance (1),  Gene:322571 (1),  Ensembl(GRCz11):ENSDARG00000003599 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:110350]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2437Tg Transgenic Insertion Intron 2 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16344 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20025 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rpl3 N/A 1
    DISEASE ASSOCIATED WITH rpl3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rpl3 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Shwachman-Diamond syndrome rpl3hi2437Tg/+; jh1Tg; jh2Tg standard conditions Provost et al., 2012
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process exocrine pancreas development (more)
    Cellular Component ribosome (more)
    Molecular Function structural constituent of ribosome (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rpl3-201 (1)    Ensembl 1382
    rpl3-202 (1)    Ensembl 738
    ncRNA rpl3-002 (1)    Ensembl 801
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rpl3 No data available
    MARKER RELATIONSHIPS
    rpl3 Contained in: [BAC] DKEY-151M15 (1) (order this)
    rpl3 Encodes: [EST] fa99g02 (1), fb65e09
    [cDNA] MGC:110350 (1), MGC:191959 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001590 (1) 1371 nt
    Genomic GenBank:BX901883 (1) 241961 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5BJJ2 (1) 403 aa
    Sequence Information (all 19)
    ORTHOLOGY for rpl3 ( Chr: 3 )
    CITATIONS (36)