Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-1262
Gene Name: serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Gene Symbol: serping1
Previous Names: fb60c09, fb62a08, fb64f02, im:7159527, si:dkeyp-110g5.2, wu:fb60c09, wu:fb62a08, wu:fb64f02 (1)
Location: Chr: 8   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7159527]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  liver, whole organism
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS No data available
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Angioedema, hereditary, types I and II 106100
Complement component 4, partial deficiency of 120790
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of complement activation (more)
Cellular Component extracellular space (more)
Molecular Function serine-type endopeptidase inhibitor activity (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000215 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR013106 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR015553 (1)
  • InterPro:IPR023796 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF00079 (1)
  • Pfam:PF07686 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA serping1-001 (1) 2045
    ncRNA serping1-002 (1) 748
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM serping1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    serping1 Contained in: [BAC] DKEYP-110G5 (1)
    serping1 Encodes: [EST] fb60c09, fb62a08, IMAGE:7159527 (1) (order this)
    serping1 Has Artifact: [EST] fb64f02
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001123285 (1) 2045 bp
    Genomic GenBank:CT025854 (1) 184858 bp
    Select Tool
    Polypeptide UniProtKB:F1RBV7 (1) 616 aa
    Sequence Clusters UniGene:36011 (1)
    Sequence Information (all 14)
    OTHER serping1 GENE PAGES
  • Gene:567801 (1)
  • VEGA:OTTDARG00000026373 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish serping1 8  
    Human SERPING1 11 (11q12.1)
  • OMIM:606860
  • Gene:710
  • Mouse Serping1 2 ( 49.45 cM)
  • MGI:894696
  • Gene:12258
  • Orthology Details
    CITATIONS (11)