Gene

serping1

ID
ZDB-GENE-030131-1262
Name
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Symbol
serping1 Nomenclature History
Previous Names
  • C1IN (1)
  • im:7159527
  • si:dkeyp-110g5.2
  • wu:fb60c09
  • wu:fb62a08
  • wu:fb64f02 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to localize to extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in angioedema (multiple); cerebral infarction; macular degeneration; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With serping1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary angioedema Alliance Angioedema, hereditary, types I and II 106100
Complement component 4, partial deficiency of 120790
Associated With serping1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013106 Immunoglobulin V-set domain
Domain IPR023796 Serpin domain
Family IPR000215 Serpin family
Family IPR015553 Plasma protease C1 inhibitor
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Homologous_superfamily IPR036186 Serpin superfamily
Homologous_superfamily IPR042178 Serpin superfamily, domain 1
Homologous_superfamily IPR042185 Serpin superfamily, domain 2
Domain Details Per Protein
Protein Length Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin V-set domain Plasma protease C1 inhibitor Serpin domain Serpin family Serpin superfamily Serpin superfamily, domain 1 Serpin superfamily, domain 2
UniProtKB:B0V2R7 604
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations