ZFIN ID: ZDB-GENE-030131-1229
Gene Name: actin, alpha 2, smooth muscle, aorta
Gene Symbol: acta2
Previous Names: sma (1), wu:fb63d03
Location: Chr: 12   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 30 figures from 12 publications
Directly Submitted Expression Data: 6 figures (6 images) from Rauch et al., 2003 [fb64d03]
  7 figures (15 images) from Thisse et al., 2004 [MGC:92120]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  adaxial cell, anterior mesenteric artery, bulbus arteriosus, dorsal aorta (all 26) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa16546
Knockdown reagents: MO1-acta2 (1)
PHENOTYPE
Data: 2 figures from Davuluri et al., 2010
Observed in: actin binding, intestine smooth muscle, intestine smooth muscle contraction, peristalsis

Phenotype of Human Orthologue OMIM Phenotype ID
Aortic aneurysm, familial thoracic 6 611788
Moyamoya disease 5 614042
Multisystemic smooth muscle dysfunction syndrome 613834
GENE ONTOLOGY
Ontology GO Term
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004000 (1)
  • InterPro:IPR004001 (1)
  • InterPro:IPR020902 (1)
  • PROSITE:PS00406 (1)
  • PROSITE:PS00432 (1)
  • PROSITE:PS01132 (1)
  • Pfam:PF00022 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA acta2-001 (1) 1369
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab2-acta2 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acta2
    Tg(acta2:EGFP), Tg(acta2:GFP), Tg(acta2:mCherry)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    acta2 Contained in: [BAC] CH73-369N22 (1) (order this)
    acta2 Encodes: [EST] fb63d03, fb64d03 (1)
    [cDNA] MGC:92120 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212620 (1) 1600 bp
    Genomic GenBank:FO704908 (1) 108766 bp
    Select Tool
    Polypeptide UniProtKB:Q6DHS1 (1) 377 aa
    Sequence Clusters UniGene:20277 (1)
    Sequence Information (all 17)
    OTHER acta2 GENE PAGES
  • Gene:322509 (1)
  • VEGA:OTTDARG00000035667 (1)
  • Ensembl(Zv9):ENSDARG00000045180 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish acta2 12  
    Human ACTA2 10 (10q23.3)
  • OMIM:102620
  • Gene:59
  • Mouse Acta2 19 ( 29.41 cM)
  • MGI:87909
  • Gene:11475
  • Orthology Details
    CITATIONS (41)