ZFIN ID: ZDB-GENE-030131-1229
Gene Name: actin, alpha 2, smooth muscle, aorta
Gene Symbol: acta2

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Previous Names: sma (1), wu:fb63d03

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(Including Attributions)
Location: Chr: 12 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 32 figures from 14 publications
Directly Submitted Expression Data: 6 figures (6 images) from Rauch et al., 2003 [fb64d03]
  7 figures (15 images) from Thisse et al., 2004 [MGC:92120]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  adaxial cell, anterior mesenteric artery, bulbus arteriosus, dorsal aorta (all 30) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16546 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35248 Point Mutation Unknown Splice Site ENU
    Targeting reagents: MO1-acta2 (1)
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in: actin binding, artery, blood circulation, heart contraction (all 8) expand
    DISEASE ASSOCIATED WITH acta2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Moyamoya disease Moyamoya disease 5 614042
    thoracic aortic aneurysm Aortic aneurysm, familial thoracic 6 611788
    Multisystemic smooth muscle dysfunction syndrome 613834
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood circulation (more)
    Cellular Component cell body (more)
    Molecular Function ATP binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004000 (1)
  • InterPro:IPR004001 (1)
  • InterPro:IPR020902 (1)
  • PROSITE:PS00406 (1)
  • PROSITE:PS00432 (1)
  • PROSITE:PS01132 (1)
  • Pfam:PF00022 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA acta2-001 (1) 1369
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab2-acta2 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM acta2
    Tg(acta2:EGFP), Tg(acta2:GFP), Tg(acta2:mCherry)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    acta2Contained in: [BAC] CH73-369N22 (1) (order this)
    acta2Encodes: [EST] fb63d03, fb64d03 (1) (order this)
    [cDNA] MGC:92120 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212620 (1) 1611bp
    Genomic GenBank:FO704908 (1) 108766bp
    Select Tool
    Polypeptide UniProtKB:Q6DHS1 (1) 377aa
    Sequence Clusters UniGene:20277 (1)
    Sequence Information (all 18)
    OTHER acta2 GENE PAGES
  • Gene:322509 (1)
  • VEGA:OTTDARG00000035667 (1)
  • Ensembl(GRCz10):ENSDARG00000045180 (1)
  • ORTHOLOGY for acta2 (Chr: 12)
    Species Symbol Chromosome Accession # Evidence
    Human ACTA2 10
  • Gene:59
  • OMIM:102620
  • HGNC:130
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Acta2 19
  • MGI:87909
  • Gene:11475
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (50)