Gene

acta2

ID
ZDB-GENE-030131-1229
Name
actin alpha 2, smooth muscle
Symbol
acta2 Nomenclature History
Previous Names
  • sma (1)
  • wu:fb63d03
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have ATP binding activity. Involved in heart contraction. Predicted to localize to several cellular components, including cell body; filopodium; and lamellipodium. Is expressed in several structures, including cardiovascular system; gut; mesoderm; musculature system; and swim bladder. Human ortholog(s) of this gene implicated in Moyamoya disease; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Orthologous to several human genes including ACTA2 (actin alpha 2, smooth muscle).
Genome Resources
Note
None
Expression
All Expression Data
40 figures from 19 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acta2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Moyamoya disease Alliance Moyamoya disease 5 614042
thoracic aortic aneurysm Alliance Aortic aneurysm, familial thoracic 6 611788
Multisystemic smooth muscle dysfunction syndrome 613834
Associated With acta2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR004001 Actin, conserved site
Conserved_site IPR020902 Actin/actin-like conserved site
Family IPR004000 Actin family
Domain Details Per Protein
Protein Length Actin/actin-like conserved site Actin, conserved site Actin family
UniProtKB:Q6TH51 377
UniProtKB:Q6DHS1 377
UniProtKB:F8W3L1 334
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-acta2 polyclonal IgG Rabbit
  • IHC
GeneTex
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations