ZFIN ID: ZDB-GENE-030131-1229
Gene Name: actin, alpha 2, smooth muscle, aorta
Gene Symbol: acta2
Previous Names: sma (1), wu:fb63d03
Location: Chr: 12   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 30 figures from 12 publications
Directly Submitted Expression Data: 6 figures (6 images) from Rauch et al., 2003 [fb64d03]
  7 figures (15 images) from Thisse et al., 2004 [MGC:92120]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  adaxial cell, anterior mesenteric artery, bulbus arteriosus, dorsal aorta (all 29) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-acta2 (1)

Allele Type Mutagen Suppliers
sa16546 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 2 figures from Davuluri et al., 2010
    Observed in: actin binding, intestine smooth muscle, intestine smooth muscle contraction, peristalsis
    DISEASE ASSOCIATED WITH acta2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    thoracic aortic aneurysm Aortic aneurysm, familial thoracic 6 611788
    Moyamoya disease Moyamoya disease 5 614042
    Multisystemic smooth muscle dysfunction syndrome 613834
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mesenchyme migration (more)
    Cellular Component cell body (more)
    Molecular Function ATP binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004000 (1)
  • InterPro:IPR004001 (1)
  • InterPro:IPR020902 (1)
  • PROSITE:PS00406 (1)
  • PROSITE:PS00432 (1)
  • PROSITE:PS01132 (1)
  • Pfam:PF00022 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA acta2-001 (1) 1369
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab2-acta2 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acta2
    Tg(acta2:EGFP), Tg(acta2:GFP), Tg(acta2:mCherry)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    acta2 Contained in: [BAC] CH73-369N22 (1) (order this)
    acta2 Encodes: [EST] fb63d03, fb64d03 (1) (order this)
    [cDNA] MGC:92120 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212620 (1) 1600 bp
    Genomic GenBank:FO704908 (1) 108766 bp
    Select Tool
    Polypeptide UniProtKB:Q6DHS1 (1) 377 aa
    Sequence Clusters UniGene:20277 (1)
    Sequence Information (all 17)
    OTHER acta2 GENE PAGES
  • Gene:322509 (1)
  • VEGA:OTTDARG00000035667 (1)
  • Ensembl(Zv9):ENSDARG00000045180 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish acta2 12  
    Human ACTA2 10 (10q23.3)
  • OMIM:102620
  • Gene:59
  • Mouse Acta2 19 ( 29.41 cM)
  • MGI:87909
  • Gene:11475
  • Orthology Details
    CITATIONS (45)