Gene

acta2

ID
ZDB-GENE-030131-1229
Name
actin alpha 2, smooth muscle
Symbol
acta2 Nomenclature History
Previous Names
  • sma (1)
  • wu:fb63d03
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have ATP binding activity. Involved in heart contraction. Predicted to localize to several cellular components, including cell body; filopodium; and lamellipodium. Human ortholog(s) of this gene implicated in Moyamoya disease; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Is expressed in several structures, including cardiovascular system; gut; mesoderm; musculature system; and swim bladder. Orthologous to several human genes including ACTA2 (actin alpha 2, smooth muscle).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
45 figures from 22 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acta2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Moyamoya disease Alliance Moyamoya disease 5 614042
thoracic aortic aneurysm Alliance Aortic aneurysm, familial thoracic 6 611788
Multisystemic smooth muscle dysfunction syndrome 613834
Associated With acta2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR004001 Actin, conserved site
Conserved_site IPR020902 Actin/actin-like conserved site
Family IPR004000 Actin family
Homologous_superfamily IPR043129 ATPase, nucleotide binding domain
Domain Details Per Protein
Protein Length Actin/actin-like conserved site Actin, conserved site Actin family ATPase, nucleotide binding domain
UniProtKB:F8W3L1 334
UniProtKB:Q6TH51 377
UniProtKB:Q6DHS1 377
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-acta2 polyclonal IgG Rabbit
  • IHC
GeneTex
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations