ZFIN ID: ZDB-GENE-030131-1229
Gene Name: actin alpha 2, smooth muscle
Gene Symbol: acta2    Nomenclature History

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Previous Names: sma (1), wu:fb63d03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have ATP binding activity. Involved in heart contraction. Predicted to localize to several cellular components, including cell body; filopodium; and lamellipodium. Is expressed in several structures, including cardiovascular system; gut; mesoderm; musculature system; and swim bladder. Human ortholog(s) of this gene implicated in Moyamoya disease; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Orthologous to several human genes including ACTA2 (actin alpha 2, smooth muscle).
Genome Resources: Alliance (1),  Gene:322509 (1),  Ensembl(GRCz11):ENSDARG00000045180 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16546 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35248 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-acta2 N/A 4
    DISEASE ASSOCIATED WITH acta2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Moyamoya disease Alliance Moyamoya disease 5 614042
    thoracic aortic aneurysm Alliance Aortic aneurysm, familial thoracic 6 611788
    Multisystemic smooth muscle dysfunction syndrome 613834
    DISEASE ASSOCIATED WITH acta2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood circulation (more)
    Cellular Component cell body (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acta2-201 (1)    Ensembl 1369
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-acta2 polyclonal IgG Rabbit IHC GeneTex
    2
    CONSTRUCTS WITH SEQUENCES FROM acta2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(acta2-hsp70l:EGFP) acta2hsp70l EGFP Danio rerio 1 1
    Tg(acta2:EGFP) acta2 EGFP Danio rerio 1 15
    tg(acta2:gal4ff,myl7:egfp) acta2myl7 EGFPGAL4FF Danio rerio 1 1
    Tg(acta2:GFP) acta2 GFP Danio rerio 1 2
    Tg(acta2:mCherry) acta2 mCherry Danio rerio 1 7
    Tg2(acta2:mCherry) acta2 mCherry Danio rerio 1 2
    TgBAC(acta2:EGFP) acta2 EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    acta2 Contained in: [BAC] CH73-369N22 (1)
    acta2 Encodes: [EST] fb63d03, fb64d03 (1) (order this)
    [cDNA] MGC:92120 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212620 (1) 1600 nt
    Genomic GenBank:FO704908 (1) 108766 nt
    Select Tool
    Polypeptide UniProtKB:Q6DHS1 (1) 377 aa
    Sequence Information (all 18)
    ORTHOLOGY for acta2 ( Chr: 12 )
    CITATIONS (81)