ZFIN ID: ZDB-GENE-030128-4
Gene Name: SMAD family member 3b
Gene Symbol: smad3b    Nomenclature History

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Previous Names: madh3b, Smad3b (1), zgc:92234

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription, DNA-templated and transforming growth factor beta receptor signaling pathway. Predicted to localize to cytoplasm; nucleus; and transcription regulator complex. Is expressed in several structures, including immature eye; lateral mesoderm; margin; nervous system; and tail bud. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3).
Genome Resources: Alliance (1),  Gene:326283 (1),  Ensembl(GRCz11):ENSDARG00000010207 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11128 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36632 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-smad3b N/A 1
    MO2-smad3b N/A 1
    MO3-smad3b N/A 3
    DISEASE ASSOCIATED WITH smad3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Loeys-Dietz syndrome 3 Alliance Loeys-Dietz syndrome 3 613795
    DISEASE ASSOCIATED WITH smad3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smad3b-201 (1)    Ensembl 2167
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smad3b No data available
    MARKER RELATIONSHIPS
    smad3b Contained in: [BAC] DKEY-85G12 (1) (order this), DKEY-288J18 (1) (order this)
    smad3b Encodes: [cDNA] MGC:92234 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_175083 (1) 2030 nt
    Genomic GenBank:CR533570 (1) 167352 nt
    Select Tool
    Polypeptide UniProtKB:Q66HX9 (1) 423 aa
    Sequence Information (all 13)
    ORTHOLOGY for smad3b ( Chr: 18 )
    CITATIONS (40)