ZFIN ID: ZDB-GENE-030124-1
Gene Name: nuclear factor, erythroid 2
Gene Symbol: nfe2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including otic vesicle morphogenesis; regulation of primitive erythrocyte differentiation; and swim bladder inflation. Localizes to transcription regulator complex. Is expressed in blood; otic placode; otic vesicle; ventral mesenchyme; and ventral mesoderm. Orthologous to human NFE2 (nuclear factor, erythroid 2).
Genome Resources: Alliance (1),  Gene:317765 (1),  Ensembl(GRCz11):ENSDARG00000020606 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 3 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2005 [eu729]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mi4002 Small Deletion Unknown Frameshift, Premature Stop TALEN
sa24387 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32462 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nfe2
    2
    MO1-nfe2 N/A 1
    MO2-nfe2 N/A 1
    MO3-nfe2 N/A 1
    TALEN1-nfe2 2
    DISEASE ASSOCIATED WITH nfe2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nfe2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood coagulation (more)
    Cellular Component transcription regulator complex (more)
    Molecular Function CONTRIBUTES_TO   DNA binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nfe2-201 (1)    Ensembl 1640
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nfe2 No data available
    MARKER RELATIONSHIPS
    nfe2 Contained in: [BAC] DKEY-174K1 (1) (order this)
    nfe2 Encodes: [EST] eu729 (1)
    [cDNA] MGC:193768 (1), MGC:193781 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_175043 (1) 1331 nt
    Genomic GenBank:BX571773 (1) 135439 nt
    Select Tool
    Polypeptide UniProtKB:F1QWY1 (1) 466 aa
    Sequence Information (all 26)
    ORTHOLOGY for nfe2 ( Chr: 23 )
    CITATIONS (41)