ZFIN ID: ZDB-GENE-030116-2
Gene Name: estrogen receptor 2a
Gene Symbol: esr2a
Sequence Ontology ID : SO:0000704

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Previous Names: ER[b]2 (1), ER[b]a (1), ERbeta-B (1), NR3A2-B (1), zfER[b]2 (1)

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding activity and steroid hormone binding activity; involved in response to estrogen; predicted  ...
GENE EXPRESSION
All Expression Data: 26 figures from 16 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu81]
  7 figures (7 images) from Thisse et al., 2008 [bc044349]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb295 Small Deletion Unknown Unknown CRISPR
ihb296 Insertion Unknown Unknown CRISPR
la021455Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16405 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25133 Point Mutation Unknown Premature Stop ENU
    sa37010 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • uab134 Small Deletion Unknown Frameshift, Premature Stop CRISPR
    zf1081 Small Deletion Exon 2 Premature Stop CRISPR
    zf1082 Small Deletion Exon 2 Premature Stop CRISPR
    Targeting reagents:
    PHENOTYPE
    Data: 10 figures from 3 publications
    Observed in:
    DISEASE ASSOCIATED WITH esr2a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    ovarian dysgenesis 8 ?Ovarian dysgenesis 8 618187
    DISEASE ASSOCIATED WITH esr2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to estrogen (more)
    Cellular Component nucleus (more)
    Molecular Function estrogen receptor activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000536 (1)
  • InterPro:IPR001628 (1)
  • InterPro:IPR001723 (1)
  • InterPro:IPR013088 (1)
  • InterPro:IPR021064 (1)
  • InterPro:IPR024178 (1)
  • InterPro:IPR028355 (1)
  • InterPro:IPR035500 (1)
  • PROSITE:PS00031 (1)
  • PROSITE:PS51030 (1)
  • PROSITE:PS51843 (1)
  • Pfam:PF00104 (1)
  • Pfam:PF00105 (1)
  • Pfam:PF12497 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA esr2a-001 (1) 3249
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM esr2a No data available
    MARKER RELATIONSHIPS
    esr2aContained in: [BAC] DKEY-274C14 (1) (order this)
    esr2aEncodes: [EST] bc044349 (1) (order this), eu81 (1), fi14h07
    [cDNA] MGC:55251 (1) (order this), MGC:192492 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_180966 (1) 3111bp
    Genomic GenBank:BX255911 (1) 206480bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q7ZU32 (1) 553aa
    Sequence Clusters UniGene:80416 (1)
    Sequence Information (all 34)
    OTHER esr2a GENE PAGES
  • Alliance (1)
  • Gene:317734 (1)
  • VEGA:OTTDARG00000004945 (1)
  • Ensembl(GRCz11):ENSDARG00000016454 (2)
  • ORTHOLOGY for esr2a (Chr: 20)
    CITATIONS (138)