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Gene

rock2a

ID
ZDB-GENE-030115-3
Name
rho-associated, coiled-coil containing protein kinase 2a
Symbol
rock2a Nomenclature History
Previous Names
  • rock2 (1)
  • rok2 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable Rho-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including gastrulation; protein catabolic process in the vacuole; and regulation of actin cytoskeleton organization. Located in plasma membrane. Is expressed in corneal epithelium; fin bud; midbrain hindbrain boundary; otic vesicle; and pharyngeal arch 3-7. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Lisowska et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rock2a Human Ortholog
No data available
Associated With rock2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR001849 Pleckstrin homology domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR015008 ROCK, Rho binding domain
Domain IPR037311 Rho-associated protein kinase 2, HR1 domain
Family IPR020684 Rho-associated protein kinase 1/2
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal PH-like domain superfamily Pleckstrin homology domain Protein kinase, ATP binding site Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Protein kinase domain Protein kinase-like domain superfamily Rho-associated protein kinase 1/2 Rho-associated protein kinase 2, HR1 domain ROCK, Rho binding domain Serine/threonine-protein kinase, active site
UniProtKB:Q90Y37 1375
UniProtKB:A0A0R4IHT4 1396
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations