ZFIN ID: ZDB-GENE-030114-7
Gene Name: leucyl-tRNA synthetase 1b
Gene Symbol: lars1b    Nomenclature History

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Previous Names: lars, larsb, cb667 (1), wu:fb36b12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation. Is expressed in several structures, including alar plate midbrain region; brain; digestive system; mesoderm; and musculature system. Orthologous to human LARS1 (leucyl-tRNA synthetase 1).
Genome Resources: Alliance (1),  Gene:569778 (1),  Ensembl(GRCz11):ENSDARG00000019280 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cq68 Indel Unknown Unknown CRISPR
sa15597 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39348 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lars1b 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lars1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Infantile liver failure syndrome 1 615438
    DISEASE ASSOCIATED WITH lars1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process leucyl-tRNA aminoacylation (more)
    Molecular Function aminoacyl-tRNA editing activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA larsb-202 (1)    Ensembl 2973
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lars1b No data available
    MARKER RELATIONSHIPS
    lars1b Contained in: [BAC] DKEY-83D6 (1) (order this)
    lars1b Encodes: [EST] cb667 (1) (order this), fb36b12
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_693187 (1)
    Genomic GenBank:CU302322 (1) 218024 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QFN3 (1) 799 aa
    Sequence Information (all 24)
    ORTHOLOGY for lars1b ( Chr: 21 )
    CITATIONS (20)