Gene

lars1b

ID
ZDB-GENE-030114-7
Name
leucyl-tRNA synthetase 1b
Symbol
lars1b Nomenclature History
Previous Names
  • lars
  • larsb
  • cb667 (1)
  • wu:fb36b12
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation. Is expressed in several structures, including alar plate midbrain region; brain; digestive system; mesoderm; and musculature system. Used to study infantile liver failure syndrome 1. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Wang et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lars1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
infantile liver failure syndrome 1 Alliance ?Infantile liver failure syndrome 1 615438
Associated With lars1b Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002300 Aminoacyl-tRNA synthetase, class Ia
Domain IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
Domain IPR015413 Methionyl/Leucyl tRNA synthetase
Family IPR004493 Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic
Homologous_superfamily IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Homologous_superfamily IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ia Aminoacyl-tRNA synthetase, class Ia, anticodon-binding Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic Methionyl/Leucyl tRNA synthetase Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding Rossmann-like alpha/beta/alpha sandwich fold Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
UniProtKB:F1RAQ9 748
UniProtKB:F1QFN3 799
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations