ZFIN ID: ZDB-GENE-030109-1
Gene Name: RuvB-like AAA ATPase 2
Gene Symbol: ruvbl2    Nomenclature History

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Previous Names: liebeskummer (1), lik (1), reptin, wu:fi25f01, zreptin

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits ATPase activity. Involved in several processes, including cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and regulation of heart growth. Predicted to localize to the R2TP complex and nuclear lumen. Is expressed in central nervous system; neural tube; posterior lateral line; and pronephric duct. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2).
Genome Resources: Alliance (1),  Gene:317678 (1),  Ensembl(GRCz11):ENSDARG00000055639 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63723]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fw039k Point Mutation Intron 7 Cryptic Acceptor Splice Site ENU
hi2394Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40466 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ruvbl2 N/A 1
    MO2-ruvbl2 N/A 1
    DISEASE ASSOCIATED WITH ruvbl2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ruvbl2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component MLL1 complex (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003593 AAA+ ATPase domain
    Domain IPR010339 TIP49, P-loop domain
    Family IPR027238 RuvB-like
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Family IPR037942 RuvB-like helicase 2
    Domain IPR041048 RuvB-like, AAA-lid domain
    Homologous_superfamily IPR042487 RuvB-like helicase 2, domain II
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ruvbl2-201 (1)    Ensembl 1712
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ruvbl2 polyclonal IgG Rabbit IHC, WB Abcam plc
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ruvbl2 No data available
    MARKER RELATIONSHIPS
    ruvbl2 Contained in: [BAC] DKEY-7B17 (1) (order this)
    ruvbl2 Encodes: [EST] fi25f01
    [cDNA] MGC:63723 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_174860 (1) 1735 bp
    Genomic GenBank:BX276103 (1) 189322 bp
    Select Tool
    Polypeptide UniProtKB:P83571 (1) 463 aa
    Sequence Information (all 14)
    ORTHOLOGY for ruvbl2 ( Chr: 5 )
    CITATIONS (38)