ZFIN ID: ZDB-GENE-021231-1
Gene Name: insulin-like growth factor binding protein 1a
Gene Symbol: igfbp1a    Nomenclature History

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Previous Names: cb656 (1), igfbp1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in negative regulation of cell population proliferation; regeneration; and response to hypoxia. Localizes to cytoplasm. Is expressed in several structures, including adaxial cell; brain; cardiovascular system; digestive system; and retina. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1).
Genome Resources: Alliance (1),  Gene:317638 (1),  Ensembl(GRCz11):ENSDARG00000099351 (1)
GENE EXPRESSION
All Expression Data: 25 figures from 13 publications
Directly Submitted Expression Data: 6 figures (33 images) from Thisse et al., 2001 [cb656]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa45687 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-igfbp1a N/A 2
    MO2-igfbp1a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH igfbp1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH igfbp1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of cell population proliferation (more)
    Cellular Component cytoplasm (more)
    Molecular Function insulin-like growth factor I binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA igfbp1a-202 (1)    Ensembl 1773
    ncRNA igfbp1a-002 (1)    Ensembl 817
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM igfbp1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(actb2:igfbp1a,myl7:EGFP) actb2myl7 EGFPigfbp1a Danio rerio 3 1
    MARKER RELATIONSHIPS
    igfbp1a Contained in: [BAC] DKEY-162M2 (1) (order this)
    igfbp1a Encodes: [EST] cb656 (1) (order this)
    [cDNA] MGC:65812 (1), MGC:77333 (1)
    igfbp1a Has Artifact: [EST] fb68e07
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_173283 (1) 1745 nt
    Genomic GenBank:CR926131 (1) 193882 nt
    Select Tool
    Polypeptide UniProtKB:A0A0B5JK49 (1) 262 aa
    Sequence Information (all 25)
    ORTHOLOGY for igfbp1a ( Chr: 20 )
    CITATIONS (85)