Gene

lamb1a

ID
ZDB-GENE-021226-1
Name
laminin, beta 1a
Symbol
lamb1a Nomenclature History
Previous Names
  • lamb1
  • cb95 (1)
  • fc20b05
  • grumpy
  • gup
  • sb:cb95
  • wu:fc20b05
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have integrin binding activity. Predicted to be an extracellular matrix structural constituent. Involved in several processes, including animal organ development; detection of light stimulus involved in visual perception; and fin regeneration. Predicted to localize to laminin complex. Is expressed in several structures, including digestive system; fin; nervous system; optic cup; and pectoral fin bud. Used to study coloboma. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly. Orthologous to human LAMB1 (laminin subunit beta 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
54 figures from 22 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lamb1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lissencephaly 5 Alliance Lissencephaly 5 615191
Associated With lamb1a Via Experimental Models
Human Disease Fish Conditions Citations
coloboma lamb1am189/m189 standard conditions Moosajee et al., 2008
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR002049 Laminin EGF domain
Domain IPR008211 Laminin, N-terminal
Domain IPR013015 Laminin IV type B
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR038684 Laminin, N-terminal domain superfamily
Domain Details Per Protein
Protein Length EGF-like domain Galactose-binding-like domain superfamily Laminin EGF domain Laminin IV type B Laminin, N-terminal Laminin, N-terminal domain superfamily
UniProtKB:A0A0R4IY30 551
UniProtKB:Q5BJ05 401
UniProtKB:A0A0R4IDN1 1785
UniProtKB:Q8JHV7 1785
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations