ZFIN is now using GRCz12tu for Genomic Data
Gene
lamb1a
- ID
- ZDB-GENE-021226-1
- Name
- laminin, beta 1a
- Symbol
- lamb1a Nomenclature History
- Previous Names
-
- lamb1
- cb95 (1)
- fc20b05
- grumpy
- gup
- sb:cb95
- wu:fc20b05
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables mechanoreceptor activity. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; determination of left/right asymmetry in lateral mesoderm; and nervous system development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of laminin complex. Is expressed in several structures, including digestive system; eye; fin; heart; and optic cup. Used to study coloboma. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly 5. Orthologous to human LAMB1 (laminin subunit beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb95 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 64 figures from 24 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lissencephaly 5 | Alliance | Lissencephaly 5 | 615191 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| coloboma | lamb1am189/m189 | standard conditions | (2) |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Galactose-binding-like domain superfamily | Laminin IV type B | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JHV7 | InterPro | 1785 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lamb1a-201
(1)
|
Ensembl | 1,654 nt | ||
| mRNA |
lamb1a-202
(1)
|
Ensembl | 5,358 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers