Gene

lamb1a

ID

ZDB-GENE-021226-1

Name

laminin, beta 1a

Symbol

lamb1a Nomenclature History

Previous Names

lamb1
cb95 (1)
fc20b05
grumpy
gup
sb:cb95
wu:fc20b05

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have extracellular matrix structural constituent and integrin binding activity. Involved in several processes, including animal organ development; detection of light stimulus involved in visual perception; and fin regeneration. Predicted to localize to laminin complex. Is expressed in several structures, including digestive system; fin; nervous system; optic cup; and pectoral fin bud. Used to study coloboma. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly. Orthologous to human LAMB1 (laminin subunit beta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb95 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 58 figures from 23 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lamb1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lissencephaly 5	Alliance	Lissencephaly 5	615191

Associated With lamb1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
coloboma	lamb1a^m189/m189	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR008211	Laminin, N-terminal
Domain	IPR013015	Laminin IV type B
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily