ZFIN ID: ZDB-GENE-021223-1
Gene Name: dystroglycan 1
Gene Symbol: dag1    Nomenclature History

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Previous Names: dag, dystrophin-associated glycoprotein 1, wu:fb83d06, wu:fi25f06, wu:fi37b08, zgc:109786

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Exhibits laminin binding activity. Involved in several processes, including T-tubule organization; skeletal muscle organ development; and somatic muscle development. Localizes to sarcolemma. Is expressed in several structures, including mesoderm; nervous system; pronephros; somite; and trunk musculature. Used to study muscular dystrophy-dystroglycanopathy. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Orthologous to human DAG1 (dystroglycan 1).
Genome Resources: Alliance (1),  Gene:286829 (1),  Ensembl(GRCz11):ENSDARG00000016153 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cl500 Point Mutation Unknown Missense ENU
hu3072 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • hu3395 Point Mutation Unknown Unknown ENU
    sa8855 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11376 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43877 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dag1 N/A 15
    MO2-dag1 N/A 1
    DISEASE ASSOCIATED WITH dag1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive limb-girdle muscular dystrophy type 2P Alliance Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 9 613818
    congenital muscular dystrophy-dystroglycanopathy type A9 Alliance Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 9 616538
    DISEASE ASSOCIATED WITH dag1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    muscular dystrophy-dystroglycanopathy WT + MO1-dag1 standard conditions Goody et al., 2012
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process muscle attachment (more)
    Cellular Component sarcolemma (more)
    Molecular Function laminin binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dag1-201 (1)    Ensembl 3596
    dag1-202 (1)    Ensembl 5674
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-dag1 monoclonal IgM Mouse IHC, WB Santa Cruz Biotechnology, Inc.
    Millipore
    14
    Ab5-dag1 polyclonal Rabbit WB 2
    Ab3-dag1 monoclonal IgG2a Mouse IHC, WB Leica Microsystems Inc.
    25
    Ab2-dag1 monoclonal IgG1 Mouse IHC, WB Millipore
    5
    Ab4-dag1 monoclonal IgG1 , l Mouse IHC, WB Developmental Studies Hybridoma Bank
    6
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dag1 No data available
    MARKER RELATIONSHIPS
    dag1 Contained in: [BAC] CH73-345H12 (1)
    dag1 Encodes: [EST] eu576 (1), fb83d06, fi25f06 (1), fi37b08
    [cDNA] MGC:109786 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_173274 (1) 3626 nt
    Genomic GenBank:CU658285 (1) 94264 nt
    Select Tool
    Polypeptide UniProtKB:F1QMH7 (1) 866 aa
    Sequence Information (all 27)
    ORTHOLOGY for dag1 ( Chr: 22 )
    CITATIONS (65)